Figure 6. Relative quantities of totPrPD and resPrPD in T1–T3 phenotypes. totPrPD accounted for 93.1% and resPrPD for 81.3% of total PrP recovered from bank voles harboring the T1 phenotype. Corresponding percentages for T2 were 91.0% and 33.0%, and T3 totPrPD and resPrPD accounted only for 8.0% and 0.2% of total PrP and differed significantly from both T1 and T2 in each of the 2 components. ResPrPD also differed significantly between T1 and T2 (each bar represents the mean ± SD of n = 3 T1, n = 3 T2, and n = 5 T3; all data are from bank voles 109I; antibody 9A2). bv, bank vole; resPrPD protease-resistant, disease-related prion protein; totPrPD, comprising protease-sensitive PrPD and resPrPD. *p<0.0001; †p<0.0001 vs. T1 and p<0.05 vs. T2; ‡p<0.01.