Volume 25, Number 1—January 2019
Research
Variable Protease-Sensitive Prionopathy Transmission to Bank Voles
Table 1
VPSPr transmission to bank voles*
Inoculum | Bv109I |
Bv109M |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1st passage |
2nd passage |
1st passage |
2nd passage |
|||||||||||||
PrPD type | Attack rate | Survival time, dpi ± SD | PrPD type | Attack rate | Survival time, dpi ± SD | Survival reduction, % | PrPD type | Attack rate | DPI | PrPD type | Attack rate | Survival time, dpi ± SD | ||||
VPSPr-MM, n = 2 |
T1 | 1/20† | 901 | NA | NA | NA | NA | T1 |
1/15 |
356 |
T1 |
11/11 |
148 ± 12 |
|||
T2 | 1/20 | 839 | NA | NA | NA | NA | ||||||||||
T3 |
5/20 |
413 ± 102 |
T3 |
9/9 |
247 ± 35‡ |
40 |
||||||||||
VPSPr-MV, n = 3 |
T1 | 13/44† | 458 ± 137 | T1 | 10/10 | 195 ± 9§ | 57 | T1 |
2/30 |
290, 588 |
T1 |
11/11 |
142 ± 11 |
|||
T2 | 6/44 | 872 ± 110¶ | T2 | 14/14 | 338 ± 100# | 61 | ||||||||||
T3 |
1/44 |
554 |
NA |
NA |
NA |
NA |
||||||||||
VPSPr-VV, n = 2 | T3 | 2/18 | 596, 535 | T3 | 9/9 | 255 ± 24** | 55 | NA | 0/14 | NA | NA | NA | NA |
*bv, bank voles; dpi: days post inoculation; NA, not available; neg, negative; PRPD, disease-associated prion protein; VPSPr, variably protease-sensitive prionopathy.
†Total no. bank voles inoculated with either VPSPr-MM or VPSPr-MV; statistics of survival times at 1st vs. 2nd passages.
‡p<0.05,
§p<0.0001.
¶Incubation periods of T2 vs. T1 p<0.0001.
#p<0.0001.
**p<0.001.
1These authors contributed equally to this article.