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Volume 25, Number 1—January 2019

Research

Variable Protease-Sensitive Prionopathy Transmission to Bank Voles

Romolo Nonno1, Silvio Notari1, Michele Angelo Di Bari, Ignazio Cali, Laura Pirisinu, Claudia d’Agostino, Laura Cracco, Diane Kofskey, Ilaria Vanni, Jody Lavrich, Piero Parchi, Umberto Agrimi, and Pierluigi GambettiComments to Author 
Author affiliations: Istituto Superiore di Sanità, Rome, Italy (R. Nonno, M.A. Di Bari, L. Pirisinu, C. d’Agostino, I. Vanni, U. Agrimi); Case Western Reserve University, Cleveland, Ohio, USA (S. Notari, I. Cali, L. Cracco, D. Kofskey, J. Lavrich, P. Gambetti); University of Bologna, Bologna, Italy (P. Parchi); Istituto delle Scienze Neurologiche di Bologna, Bologna (P. Parchi)

Main Article

Table 1

VPSPr transmission to bank voles*

Inoculum Bv109I
 Bv109M
1st passage
 2nd passage
 1st passage
 2nd passage
PrPD type Attack rate Survival time, dpi ± SD PrPD type Attack rate Survival time, dpi ± SD Survival reduction, % PrPD type Attack rate DPI PrPD type Attack rate Survival time, dpi ± SD
VPSPr-MM, n = 2
 T1 1/20† 901 NA NA NA NA T1
 1/15
 356
T1
 11/11
 148 ± 12
T2 1/20 839 NA NA NA NA
T3
 5/20
 413 ± 102
T3
 9/9
 247 ± 35‡
 40
VPSPr-MV, n = 3
 T1 13/44† 458 ± 137 T1 10/10 195 ± 9§ 57 T1
 2/30
 290, 588
T1
 11/11
 142 ± 11
T2 6/44 872 ± 110¶ T2 14/14 338 ± 100# 61
T3
 1/44
 554
NA
 NA
 NA
 NA
VPSPr-VV, n = 2 T3 2/18 596, 535 T3 9/9 255 ± 24** 55 NA 0/14 NA NA NA NA

*bv, bank voles; dpi: days post inoculation; NA, not available; neg, negative; PRPD, disease-associated prion protein; VPSPr, variably protease-sensitive prionopathy.
†Total no. bank voles inoculated with either VPSPr-MM or VPSPr-MV; statistics of survival times at 1st vs. 2nd passages.
‡p<0.05,
§p<0.0001.
¶Incubation periods of T2 vs. T1 p<0.0001.
#p<0.0001.
**p<0.001.

Main Article

1These authors contributed equally to this article.

Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
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