Variable Protease-Sensitive Prionopathy Transmission to Bank Voles
Romolo Nonno
1, Silvio Notari
1, Michele Angelo Di Bari, Ignazio Cali, Laura Pirisinu, Claudia d’Agostino, Laura Cracco, Diane Kofskey, Ilaria Vanni, Jody Lavrich, Piero Parchi, Umberto Agrimi, and Pierluigi Gambetti
Author affiliations: Istituto Superiore di Sanità, Rome, Italy (R. Nonno, M.A. Di Bari, L. Pirisinu, C. d’Agostino, I. Vanni, U. Agrimi); Case Western Reserve University, Cleveland, Ohio, USA (S. Notari, I. Cali, L. Cracco, D. Kofskey, J. Lavrich, P. Gambetti); University of Bologna, Bologna, Italy (P. Parchi); Istituto delle Scienze Neurologiche di Bologna, Bologna (P. Parchi)
Main Article
Table 2
Itemized VPSPr transmission features in bv109I at first passage, by phenotype*
Genotype
|
T1 |
|
T2 |
|
T3 |
Attack rate for all phenotypes, %
|
Prevalence, %
|
Survival time, dpi ± SD
|
Prevalence, %
|
Survival time, dpi ± SD
|
Prevalence, %
|
Survival time, dpi ± SD
|
MM |
5 |
901 |
|
5 |
839 |
|
25 |
413 ± 102† |
35 |
MV |
29.5 |
458 ± 137† |
|
13.6 |
872 ± 110† |
|
2.3 |
554 |
45.5 |
VV |
0 |
NA |
|
0 |
NA |
|
11.1 |
596, 535 |
11.1 |
All affected genotypes |
11.5‡ |
490 ± 177† |
|
6.2‡ |
867 ± 101† |
|
12.8‡ |
469 ± 110† |
30.5‡ |
Main Article
Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
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