Chad E. Mire, Joan B. Geisbert, Krystle N. Agans, Krista M. Versteeg, Daniel J. Deer, Benjamin A. Satterfield1
, Karla A. Fenton, and Thomas W. Geisbert
Figure 2. Protection of African green monkeys (Chlorocebus aethiops) from Nipah virus Bangladesh strain (NiVB)–mediated disease and viral load. A) Kaplan-Meier survival curve for each vaccine group and historical controls after NiVB challenge: controls (vaccine, n = 1; historical, n = 14), F group (n = 3), G group (n = 3), and F/G group (n = 3). C–D) Viral load in the animals as detected by NiVB GEq by reverse transcription quantitative PCR from nasal swab samples: as GEq per swab (B), oral swab samples as GEq per swab (C), and blood as GEq/mL (D). Red, control group (GInd*rVSV-ΔG-GFP expressing no glycoprotein); blue, F group (GInd* rVSV-NiVB /F-GFP expressing the NiVB F protein); yellow, G group (GInd*rVSV-NiVB/G-GFP expressing the NiVB G protein); green, F/G group (single-cycle infectious virions with NiVB F and G proteins on the cell surface). Error bars indicate SD. C, control; F, fusion; G, attachment; GEq, genome equivalent.