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Volume 25, Number 6—June 2019
Research

Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease

Chad E. Mire, Joan B. Geisbert, Krystle N. Agans, Krista M. Versteeg, Daniel J. Deer, Benjamin A. Satterfield1, Karla A. Fenton, and Thomas W. GeisbertComments to Author 
Author affiliations: Galveston National Laboratory, Galveston, Texas, USA; University of Texas Medical Branch, Galveston

Main Article

Figure 2

Protection of African green monkeys (Chlorocebus aethiops) from Nipah virus Bangladesh strain (NiVB)–mediated disease and viral load. A) Kaplan-Meier survival curve for each vaccine group and historical controls after NiVB challenge: controls (vaccine, n = 1; historical, n = 14), F group (n = 3), G group (n = 3), and F/G group (n = 3). C–D) Viral load in the animals as detected by NiVB GEq by reverse transcription quantitative PCR from nasal swab samples: as GEq per swab (B), oral swab samples a

Figure 2. Protection of African green monkeys (Chlorocebus aethiops) from Nipah virus Bangladesh strain (NiVB)–mediated disease and viral load. A) Kaplan-Meier survival curve for each vaccine group and historical controls after NiVB challenge: controls (vaccine, n = 1; historical, n = 14), F group (n = 3), G group (n = 3), and F/G group (n = 3). C–D) Viral load in the animals as detected by NiVB GEq by reverse transcription quantitative PCR from nasal swab samples: as GEq per swab (B), oral swab samples as GEq per swab (C), and blood as GEq/mL (D). Red, control group (GInd*rVSV-ΔG-GFP expressing no glycoprotein); blue, F group (GInd* rVSV-NiVB /F-GFP expressing the NiVB F protein); yellow, G group (GInd*rVSV-NiVB/G-GFP expressing the NiVB G protein); green, F/G group (single-cycle infectious virions with NiVB F and G proteins on the cell surface). Error bars indicate SD. C, control; F, fusion; G, attachment; GEq, genome equivalent.

Main Article

1Current affiliation: Mayo Clinic, Rochester, Minnesota, USA.

Page created: May 20, 2019
Page updated: May 20, 2019
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