Volume 25, Number 6—June 2019
Research
Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease
Table 2
Clinical findings and outcome of Nipah virus Bangladesh strain–challenged African green monkeys*
Animal no. | Sex | Group | Clinical illness | Clinical and gross pathology findings† |
---|---|---|---|---|
C-1 |
F |
Control ΔG vaccine |
Loss of appetite (d 6–8); labored breathing (d 6–8). Died on d 8. |
Lymphopenia (d 6); serosanguinous nasal and oral discharge (d 8), serosanguinous pleural fluid, severely inflated, enlarged lungs with severe congestion and hemorrhage of all lobes, multifocal to coalescing hemorrhage of the mucosal surface of the urinary bladder. |
F-1 | F | F vaccine | None | Thrombocytopenia (d 15); >3 fold increase in ALT (d 6), >3 fold increase in AST |
F-2 | M | F vaccine | None | None |
F-3 |
M |
F vaccine |
None |
Increase in CRP (d 6) |
G-1 | F | G vaccine | None | None |
G-2 | M | G vaccine | None | None |
G-3 |
M |
G vaccine |
None |
None |
F/G-1 | F | F + G vaccine | None | Increase in CRP (d 8) |
F/G-2 | M | F + G vaccine | None | Thrombocytopenia (d 21, d 28); increase in CRP (d 8, d 10, d 15) |
F/G-3 | M | F + G vaccine | None | Thrombocytopenia (d 8) |
*ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein.
†Lymphopenia is defined as a >30% decrease in number of lymphocytes; thrombocytopenia is defined as a >30% decrease in number of platelets.
1Current affiliation: Mayo Clinic, Rochester, Minnesota, USA.
Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.