Volume 25, Number 6—June 2019
Research
Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease
Table 1
Vaccine | Animal no. | Day −28† | Day 0† | Day 28† |
---|---|---|---|---|
None |
C-1 |
<20 |
<20 |
40‡ |
F only vaccine | F-1 | <20 | 640 | 1,280 |
F-2 | <20 | 160 | 2,560 | |
F-3 |
<20 |
320 |
5,120 |
|
G only vaccine | G-1 | <20 | 640 | 5,120 |
G-2 | <20 | 640 | 5,120 | |
G-3 |
<20 |
640 |
5,120 |
|
F+G vaccine | F/G-1 | <20 | 640 | 2,560 |
F/G-2 | <20 | 640 | 5,120 | |
F/G-3 | <20 | 640 | 2,560 |
*Titers are reciprocal serum dilution at which 50% of virus was neutralized. NiV, Nipah virus; NiVB, NiV Bangladesh strain.
†Day postchallenge.
‡Terminal day 8 postchallenge.
1Current affiliation: Mayo Clinic, Rochester, Minnesota, USA.
Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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