Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin
Clément Coudereau, Alban Besnard, Marie Robbe-Saule, Céline Bris, Marie Kempf, Roch Christian Johnson, Télésphore Yao Brou, Ronald Gnimavo, Sara Eyangoh, Fida Khater, and Estelle Marion
Author affiliations: Université d’Angers, Angers, France (C. Coudereau, A. Besnard, M. Robbe-Saule, M. Kempf, F. Khater, E. Marion); INSERM, Angers (C. Coudereau, A. Besnard, M. Robbe-Saule, M. Kempf, F. Khater, E. Marion); Centre Hospitalo-Universitaire d’Angers, Angers (C. Bris, M. Kempf); Université d'Abomey Calavi, Abomey Calavi, Benin (R.C. Johnson); Fondation Raoul Follereau, Paris, France (R.C. Johnson); Maison de la Télédétection, Montpellier, France (T.Y. Brou); Centre de Diagnostic et Traitement de la Lèpre et de l’Ulcère de Buruli, Pobè, Bénin (R. Gnimavo); International Pasteur Institute Network, Yaoundé, Cameroon (S. Eyangoh)
Figure 1. Spatial distribution of Buruli ulcer patients in Benin and Nigeria. The 179 sequenced genomes of Mycobacterium ulcerans were isolated from patients in southeastern Benin; 62% came from the Ouémé region, 26% came from the Plateau region, and the remaining genomes originated from patients in Nigeria. Red dots indicate precise locations of patients’ declared place of residence. In cases where several patients were from the same village, points were slightly displaced in a circle fashion to obtain the most accurate rendering of geographic density of Buruli ulcer cases. Insets show location of Benin in West Africa and of the Ouémé and Plateau regions in Benin. CDTLUB, Centre de Diagnostic et Traitement de la Lèpre et de l’Ulcère de Buruli.
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