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Volume 26, Number 7—July 2020

Research

Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients

Nisreen M.A. Okba1, Marcel A. Müller1, Wentao Li1, Chunyan Wang, Corine H. GeurtsvanKessel, Victor M. Corman, Mart M. Lamers, Reina S. Sikkema, Erwin de Bruin, Felicity D. Chandler, Yazdan Yazdanpanah, Quentin Le Hingrat, Diane Descamps, Nadhira Houhou-Fidouh, Chantal B.E.M. Reusken, Berend-Jan Bosch, Christian Drosten, Marion P.G. Koopmans, and Bart L. HaagmansComments to Author 
Author affiliations: Erasmus Medical Center, Rotterdam, the Netherlands (N.M.A. Okba, C.H. GeurtsvanKessel, M.M. Lamers, R.S. Sikkema, E. deBruin, F.D. Chandler, C.B.E.M. Reusken, M.P.G. Koopmans, B.L. Haagmans); Charité-Universitätsmedizin Berlin, Berlin, Germany (M.A. Müller, V.M. Corman, C. Drosten); German Centre for Infection Research, Berlin (M.A. Müller, V.M. Corman, C. Drosten); Utrecht University, Utrecht, the Netherlands (W. Li, C. Wang, B.-J. Bosch); Université de Paris, Paris, France (Y. Yazdanpanah, Q. Le Hingrat, D. Descamps); Hôpital Bichat-Claude Bernard, Paris (Y. Yazdanpanah, Q. Le Hingrat, D. Descamps, N. Houhou-Fidouh); RIVM, Bilthoven, the Netherlands (C.B.E.M. Reusken)

Main Article

Table 2

Percentage amino acid identity of coronavirus spike and nucleocapsid proteins with SARS-CoV-2 proteins*

Virus type Virus Nucleocapsid S S1 S2 S1A RBD
Betacoronavirus
 SARS-CoV 90 77 66 90 52 73
MERS-CoV 49 33 24 43 ND ND
HCoV-OC43 34 33 25 42 ND ND
HCoV-HKU1
 34
 32
 25
 40
 ND
 ND
Alphacoronavirus HCoV-229E 28 30 24 35 ND ND
HCoV-NL63 29 28 21 36 ND ND

*SARS-CoV-2, HCoV-OC43, MERS-CoV, HCoV-HKU1, HCoV-NL63, SARS-CoV, HCoV-229E (GenBank accession nos. NC_045512.2, NC_006213.1, NC_019843.3, NC_006577.2, NC_005831.2, NC_004718.3, and NC_002645.1). Protein sequences were aligned by using ClustalW (https://www.genome.jp/tools-bin/clustalw). RBD, receptor-binding domain; ND, not done; S, spike; S1, N-terminal subunit of the spike protein; S2, C-terminal subunit of the spike protein; S1A, domain A of the spike S1 subunit; SARS-CoV, severe acute respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Main Article

1These authors contributed equally to this article.

Page created: April 08, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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