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Volume 26, Number 7—July 2020
Research

Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients

Nisreen M.A. Okba1, Marcel A. Müller1, Wentao Li1, Chunyan Wang, Corine H. GeurtsvanKessel, Victor M. Corman, Mart M. Lamers, Reina S. Sikkema, Erwin de Bruin, Felicity D. Chandler, Yazdan Yazdanpanah, Quentin Le Hingrat, Diane Descamps, Nadhira Houhou-Fidouh, Chantal B.E.M. Reusken, Berend-Jan Bosch, Christian Drosten, Marion P.G. Koopmans, and Bart L. HaagmansComments to Author 
Author affiliations: Erasmus Medical Center, Rotterdam, the Netherlands (N.M.A. Okba, C.H. GeurtsvanKessel, M.M. Lamers, R.S. Sikkema, E. deBruin, F.D. Chandler, C.B.E.M. Reusken, M.P.G. Koopmans, B.L. Haagmans); Charité-Universitätsmedizin Berlin, Berlin, Germany (M.A. Müller, V.M. Corman, C. Drosten); German Centre for Infection Research, Berlin (M.A. Müller, V.M. Corman, C. Drosten); Utrecht University, Utrecht, the Netherlands (W. Li, C. Wang, B.-J. Bosch); Université de Paris, Paris, France (Y. Yazdanpanah, Q. Le Hingrat, D. Descamps); Hôpital Bichat-Claude Bernard, Paris (Y. Yazdanpanah, Q. Le Hingrat, D. Descamps, N. Houhou-Fidouh); RIVM, Bilthoven, the Netherlands (C.B.E.M. Reusken)

Main Article

Table 3

Correlations between ODs/OD ratios and PRNT results of 10 serum samples obtained from 3 PCR-confirmed COVID-19 patients from France and tested in Rotterdam, the Netherlands, 6–27 d after diagnosis*

Test, virus Correlations In-house ELISAs
 Euroimmun ELISAs
S1 N RBD S S1A IgA IgG
PRNT50, SARS-CoV-2
 Spearman ρ value 0.87 0.94 0.92 0.94 0.93 0.98 0.92
2-tailed p value 0.0021 0.0002 0.0005 0.0002 0.0003 <0.0001 0.0005
p value summary
 <0.01
 <0.001
 <0.001
 <0.001
 <0.001
<0.0001
 <0.001
PRNT90, SARS-CoV-2 Spearman ρ value 0.88 0.88 0.88 0.88 0.88 0.93 0.88
2-tailed p value 0.0024 0.0024 0.0024 0.0024 0.0024 0.0008 0.002
p value summary <0.01 <0.01 <0.01 <0.01 <0.01 <0.001 <0.01

*COVID-19, coronavirus disease 2019; OD, optical density; N, nucleocapsid; PRNT50, 50% plaque reduction neutralization test; PRNT90, 90% plaque reduction neutralization test; RBD, receptor-binding domain; S, spike; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Main Article

1These authors contributed equally to this article.

Page created: April 08, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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