Volume 26, Number 8—August 2020
Synopsis
US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2
Table 7
Cross-reactivity of the US CDC rRT-PCR panel for detection of SARS-CoV-2 against other respiratory pathogens*
Pathogen (strain) | Source | Other respiratory pathogens, rRT-PCR (Ct) | SARS-CoV-2 rRT-PCR |
||
---|---|---|---|---|---|
N1 | N2 | N3 (Ct) | |||
Adenovirus C1 (Ad.71) | Virus isolate | Pos (14.0) | Neg | Neg | Neg |
Bocavirus | Clinical specimen | Pos (14.9) | Neg | Neg | Neg |
Coronavirus 229E | Virus isolate | Pos (9.6) | Neg | Neg | Neg |
Coronavirus OC43 | Virus isolate | Pos (12.9) | Neg | Neg | Neg |
Coronavirus HKU1 | Clinical specimen | Pos (22.3) | Neg | Neg | Neg |
Coronavirus MERS | Virus isolate | Pos (14.3) | Neg | Neg | Neg |
Coronavirus NL63 | Clinical specimen | Pos (21.9) | Neg | Neg | Neg |
Coronavirus SARS (Urbani) | Virus isolate | Pos (27.3) | Neg | Neg | Pos (26.3)† |
Enterovirus D68 | Virus isolate | Pos (21.3) | Neg | Neg | Neg |
Human metapneumovirus (CAN 99–81) | Virus isolate | Pos (13.8) | Neg | Neg | Neg |
Influenza A H1N1 (A/India/2012) | Virus isolate | Pos (14.7) | Neg | Neg | Neg |
Influenza A H3N1 (A/Texas/2012) | Virus isolate | Pos (10.7) | Neg | Neg | Neg |
Influenza B (B/Massachusetts/1999) | Virus isolate | Pos (8.4) | Neg | Neg | Neg |
Parainfluenza 1 (C35) | Virus isolate | Pos (17.2) | Neg | Neg | Neg |
Parainfluenza 2 (Greer) | Virus isolate | Pos (17.1) | Neg | Neg | Neg |
Parainfluenza 3 (C-43) | Virus isolate | Pos (20.4) | Neg | Neg | Neg |
Parainfluenza 4a (M-25) | Virus isolate | Pos (16.7) | Neg | Neg | Neg |
Parainfluenza 4b (CH 19503) | Virus isolate | Pos (18.2) | Neg | Neg | Neg |
Respiratory syncytial virus (Long) | Virus isolate | Pos (15.1) | Neg | Neg | Neg |
Rhinovirus 1A | Virus isolate | Pos (15.9) | Neg | Neg | Neg |
Mycoplasma pneumoniae | Cultured bacteria | Pos (20.7) | Neg | Neg | Neg |
Streptococcus pneumoniae | Cultured bacteria | Pos (21.1) | Neg | Neg | Neg |
*CDC, Centers for Disease Control and Prevention; Ct, cycle threshold; neg, negative;pos, positive; MERS, Middle East respiratory syndrome; N, nucleocapsid protein gene; rRT-PCR, real-time reverse transcription PCR; SARS-CoV-2, severe acute respiratory coronavirus 2.
†N3 assay designed for universal detection of clade 2 and 3 within Sarbecovirus subgenus including SARS-CoV-2, SARS-CoV, and bat- and civet-SARS–like coronaviruses.