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Volume 27, Number 1—January 2021
Research

Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG

Sina Schwarzkopf, Adalbert Krawczyk, Dietmar Knop, Hannes Klump, Andreas Heinold, Falko M. Heinemann, Laura Thümmler, Christian Temme, Marianne Breyer, Oliver Witzke, Ulf Dittmer, Veronika Lenz, Peter A. Horn, and Monika LindemannComments to Author 
Author affiliations: Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany (S. Schwarzkopf, D. Knop, H. Klump, A. Heinold, F.M. Heinemann, L. Thümmler, C. Temme, M. Breyer, V. Lenz, P.A. Horn, M. Lindemann); Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University of Duisburg-Essen, Essen (A. Krawczyk, O. Witzke); Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen (U. Dittmer)

Main Article

Table

Clinical characteristics of 78 potential convalescent-plasma donors with PCR-confirmed severe acute respiratory syndrome coronavirus 2 infection, grouped by antibody ratio, Germany*

Parameter Ratio <1.1 Ratio 1.1–3.0 Ratio >3.0
All donors 13 (16.7) 24 (30.8) 41 (52.6)
Age, y 45 (19–55) 51 (28–65) 47 (20–66)
Sex, M/F 6/7 19/5 29/12
Body mass index 25.2 (22.3–30.1) 24.9 (22.8–28.1) 26.7 (22.2–36.8)
Interval to onset of symptoms, d 52 (32–100) 60 (24–98) 64 (22–112)
Stay in risk area/risk contact
6
17
20
Symptoms of COVID-19 infection
Cough 7 19 30
Fever 9 13 24
Shortage of air 3 4 15
Rhinitis 7 7 16
Sore throat 6 8 15
Limb pain 7 15 19
Shivering 6 8 15
Diarrhea 5 6 15
Weight loss 3 2 9
Nausea 0 0 4
Loss of appetite 5 3 12
Headaches 7 16 26
Skin rash 1 1 1
Swelling of lymph nodes 3 0 2
Loss of sense of smell and taste
8
16
18
Necessity of oxygen supply 0 1 3
Antimicrobial treatment
1
3
7
Blood group
O 5 12 16
A 6 8 16
B 0 0 6
AB 1 3 3
ND 1 1 0

*Values are no. donors or median (range). Ratio is IgG against the S1 protein. ND, not determined.

Main Article

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