Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 3—March 2021
Research

Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections

Opeyemi U. Lawal, Maria J. Fraqueza, Ons Bouchami, Peder Worning, Mette D. Bartels, Maria L. Gonçalves, Paulo Paixão, Elsa Gonçalves, Cristina Toscano, Joanna Empel, Małgorzata Urbaś, M. Angeles Domínguez, Henrik Westh, Hermínia de Lencastre, and Maria MiragaiaComments to Author 
Author affiliations: Universidade Nova de Lisboa, Oeiras, Portugal (O.U. Lawal, O. Bouchami, H. de Lencastre, M. Miragaia); Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa, Lisbon, Portugal (M.J., Fraqueza); Hvidovre University Hospital, Hvidovre, Denmark (P. Worning, M.D. Bartels, H. Westh); SAMS Hospital, Lisbon (M.L. Gonçalves); Hospital da Luz, Lisbon (P. Paixão); Hospital Egas Moniz, Lisbon (E. Gonçalves, C. Toscano); Narodowy Instytut Leków, Warsaw, Poland (J. Empel, M. Urbaś); Hospital Universitari de Bellvitge, Barcelona, Spain (M.A. Domínguez); University of Copenhagen, Copenhagen, Denmark (H. Westh); The Rockefeller University, New York, New York, USA (H. de Lencastre)

Main Article

Figure 4

Growth rate of Staphylococcus saprophyticus clonal lineages in tryptic soy broth (TSB) and in different concentrations of female sex hormones. All assays were performed in triplicate and each experiment was repeated 3 times. A) Growth rate of S. saprophyticus strains in different concentrations of progesterone. First panel represents growth rate in TSB at 37°C; isolates belonging to lineage S grew significantly faster (p = 0.0007) than isolates in lineage G in TSB without hormones. However, no statistically significant difference in the growth rate of either lineage was noted in physiologic (2.0–200 ng/mL) and higher concentrations of progesterone. B) Growth rate of S. saprophyticus strains in TSB (first panel) and different concentrations of estradiol. Lineage S isolates grew faster in physiologic concentrations (350 pg/mL–350 ng/mL) and higher of estradiol, suggesting that this lineage is better adapted to the hormone-rich environment of the urine and the vagina than lineage G. Error bars indicate 95% CIs; horizontal lines indicate medians. C) Growth rate mean values of S. saprophyticus strains in progesterone and estradiol.

Figure 4. Growth rate of Staphylococcus saprophyticus clonal lineages in tryptic soy broth (TSB) and in different concentrations of female sex hormones. All assays were performed in triplicate and each experiment was repeated 3 times. A) Growth rate of S. saprophyticus strains in different concentrations of progesterone. First panel represents growth rate in TSB at 37°C; isolates belonging to lineage S grew significantly faster (p = 0.0007) than isolates in lineage G in TSB without hormones. However, no statistically significant difference in the growth rate of either lineage was noted in physiologic (2.0–200 ng/mL) and higher concentrations of progesterone. B) Growth rate of S. saprophyticus strains in TSB (first panel) and different concentrations of estradiol. Lineage S isolates grew faster in physiologic concentrations (350 pg/mL–350 ng/mL) and higher of estradiol, suggesting that this lineage is better adapted to the hormone-rich environment of the urine and the vagina than lineage G. Error bars indicate 95% CIs; horizontal lines indicate medians. C) Growth rate mean values of S. saprophyticus strains in progesterone and estradiol.

Main Article

Page created: December 29, 2020
Page updated: February 21, 2021
Page reviewed: February 21, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external