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Volume 28, Number 11—November 2022
Research

Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Yifan Li, Mélanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael Iroezindu, Emmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, and Morgane RollandComments to Author 
Author affiliations: Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, S.V. Mayer, J. King, C. Corbitt, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, J.A. Ake, K. Modjarrad, G. Gromowski, D. Paquin-Proulx, M. Rolland); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, D. Paquin-Proulx, M. Rolland); Institute of HIV Research and Innovation, Bangkok, Thailand (N. Phanuphak); HJF Medical Research International, Kericho, Kenya (J. Maswai, J. Owuoth, M. Iroezindu, E. Bahemana); Makerere University Walter Reed Project, Kampala, Uganda (H. Kibuuka)

Main Article

Figure 3

Comparison of antibody responses to human coronaviruses in serum and plasma samples collected before COVID-19 pandemic and from convalescent SARS-CoV-2 patients, Thailand and Africa. A) Violin plot comparing SARS-CoV-2 IgG binding responses against positive control samples. Blue dashed lines indicate median observed signal in positive control samples; pink dashed lines indicate maximum observed signal in positive control samples collected from SARS-CoV-2 convalescent patients. B) Number of coronavirus-positive samples detected by using a signal-to-noise ratio >6 across 3 outbreak coronaviruses and all antigens. C) IgG binding responses in nucleocapsid (top) and spike (bottom) proteins against all 7 human coronaviruses investigated. MERS-CoV, Middle East respiratory syndrome coronavirus; RBD, receptor-binding domain; S1, subunit 1; S2, subunit 2.

Figure 3. Comparison of antibody responses to human coronaviruses in serum and plasma samples collected before COVID-19 pandemic and from convalescent SARS-CoV-2 patients, Thailand and Africa. A) Violin plot comparing SARS-CoV-2 IgG binding responses against positive control samples. Blue dashed lines indicate median observed signal in positive control samples; pink dashed lines indicate maximum observed signal in positive control samples collected from SARS-CoV-2 convalescent patients. B) Number of coronavirus-positive samples detected by using a signal-to-noise ratio >6 across 3 outbreak coronaviruses and all antigens. C) IgG binding responses in nucleocapsid (top) and spike (bottom) proteins against all 7 human coronaviruses investigated. MERS-CoV, Middle East respiratory syndrome coronavirus; RBD, receptor-binding domain; S1, subunit 1; S2, subunit 2.

Main Article

Page created: October 01, 2022
Page updated: October 21, 2022
Page reviewed: October 21, 2022
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