Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 11—November 2022
Research

Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Yifan Li, Mélanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael Iroezindu, Emmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, and Morgane RollandComments to Author 
Author affiliations: Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, S.V. Mayer, J. King, C. Corbitt, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, J.A. Ake, K. Modjarrad, G. Gromowski, D. Paquin-Proulx, M. Rolland); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, D. Paquin-Proulx, M. Rolland); Institute of HIV Research and Innovation, Bangkok, Thailand (N. Phanuphak); HJF Medical Research International, Kericho, Kenya (J. Maswai, J. Owuoth, M. Iroezindu, E. Bahemana); Makerere University Walter Reed Project, Kampala, Uganda (H. Kibuuka)

Main Article

Figure 1

IgG responses to S2 protein among HIV-positive and HIV-negative participants in a study of coronavirus antibody responses before COVID-19 pandemic, Thailand (2013–2020) and Africa (2018–2020). A) Thailand; B) Kenya, Nigeria, Tanzania, and Uganda. We measured MFI for SARS-CoV-2 S2 IgG binding responses in 2,565 serum and plasma samples. Blue dashed line indicates maximum observed signal in 2 negative control samples; pink dashed line indicates minimum observed signal in positive control samples collected from SARS-CoV-2 convalescent patients. Symbols indicate the country of origin, collection date, and HIV-1 status of each participant. Dates indicate sample collection date. MFI, mean fluorescent intensity; S2, subunit 2 protein.

Figure 1. IgG responses to S2 protein among HIV-positive and HIV-negative participants in a study of coronavirus antibody responses before COVID-19 pandemic, Thailand (2013–2020) and Africa (2018–2020). A) Thailand; B) Kenya, Nigeria, Tanzania, and Uganda. We measured MFI for SARS-CoV-2 S2 IgG binding responses in 2,565 serum and plasma samples. Blue dashed line indicates maximum observed signal in 2 negative control samples; pink dashed line indicates minimum observed signal in positive control samples collected from SARS-CoV-2 convalescent patients. Symbols indicate the country of origin, collection date, and HIV-1 status of each participant. Dates indicate sample collection date. MFI, mean fluorescent intensity; S2, subunit 2 protein.

Main Article

Page created: October 01, 2022
Page updated: October 21, 2022
Page reviewed: October 21, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external