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Volume 28, Number 11—November 2022
Research

Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Yifan Li, Mélanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael Iroezindu, Emmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, and Morgane RollandComments to Author 
Author affiliations: Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, S.V. Mayer, J. King, C. Corbitt, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, J.A. Ake, K. Modjarrad, G. Gromowski, D. Paquin-Proulx, M. Rolland); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA (Y. Li, M. Merbah, S. Wollen-Roberts, B. Beckman, T. Mdluli, I. Swafford, H. Liu, A. Esber, S. Pinyakorn, A. Parikh, L.V. Francisco, S. Vasan, D. Paquin-Proulx, M. Rolland); Institute of HIV Research and Innovation, Bangkok, Thailand (N. Phanuphak); HJF Medical Research International, Kericho, Kenya (J. Maswai, J. Owuoth, M. Iroezindu, E. Bahemana); Makerere University Walter Reed Project, Kampala, Uganda (H. Kibuuka)

Main Article

Figure 8

Violin plots of neutralizing, ADCP, and ADCC responses in prepandemic serums and plasma samples used to study coronavirus antibody responses before COVID-19 pandemic, Thailand and Africa. A) Pseudovirus neutralization against SARS-CoV-1 and SARS-CoV-2. The plot shows fold change of the ID50 for SARS-CoV-1 or SARS-CoV-2 over the ID50 for spike glycoprotein of the vesicular stomatitis virus control pseudoviruses. B) ADCP against MERS-CoV, SARS-CoV-1, and SARS-CoV-2. C) ADCC against SARS-CoV-2. Positive threshold is defined as mean of the negative control samples +3 SD. Solid lines link each sample between plots. Dotted lines indicate positive thresholds for each assay. Samples are color-coded for the participant’s country of origin. ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; ID50, 50% inhibitory dilution; MERS-CoV, Middle East respiratory syndrome coronavirus.

Figure 8. Violin plots of neutralizing, ADCP, and ADCC responses in prepandemic serums and plasma samples used to study coronavirus antibody responses before COVID-19 pandemic, Thailand and Africa. A) Pseudovirus neutralization against SARS-CoV-1 and SARS-CoV-2. The plot shows fold change of the ID50 for SARS-CoV-1 or SARS-CoV-2 over the ID50 for spike glycoprotein of the vesicular stomatitis virus control pseudoviruses. B) ADCP against MERS-CoV, SARS-CoV-1, and SARS-CoV-2. C) ADCC against SARS-CoV-2. Positive threshold is defined as mean of the negative control samples +3 SD. Solid lines link each sample between plots. Dotted lines indicate positive thresholds for each assay. Samples are color-coded for the participant’s country of origin. ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; ID50, 50% inhibitory dilution; MERS-CoV, Middle East respiratory syndrome coronavirus.

Main Article

Page created: October 01, 2022
Page updated: October 21, 2022
Page reviewed: October 21, 2022
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