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Volume 28, Number 6—June 2022

Research

Risk Prediction Score for Pediatric Patients with Suspected Ebola Virus Disease

Alicia E. Genisca1Comments to Author , Tzu-Chun Chu1, Lawrence Huang, Monique Gainey, Moyinoluwa Adeniji, Eta N. Mbong, Stephen B. Kennedy, Razia Laghari, Fiston Nganga, Rigo F. Muhayangabo, Himanshu Vaishnav, Shiromi M. Perera, Andrés Colubri2, Adam C. Levine2, and Ian C. Michelow23Comments to Author 
Author affiliations: Brown Emergency Medicine, Providence, Rhode Island, USA (A.E. Genisca, H. Vaishnav, A.C. Levine); Alpert Medical School of Brown University, Providence (A.E. Genisca, A.C. Levine, I.C. Michelow); University of Georgia, Athens, Georgia, USA (T.C. Chu); Brown University, Providence (L. Huang, M. Adeniji); Rhode Island Hospital, Providence (M. Gainey); International Medical Corps, Goma, Democratic Republic of the Congo (E.N. Mbong, R. Laghari, F. Nganga, R.F. Muhayangabo); Ministry of Health, Monrovia, Liberia (S.B. Kennedy); International Medical Corps, Washington, DC, USA (S.M. Perera); University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA (A. Colubri)

Main Article

Table 1

Demographic and clinical characteristics of patients, by EVD status at triage, in West Africa, September 2014 – September 2015*

Characteristics Total, no (%), n = 521 EVD positive, no. (%), n = 120 (23%) EVD negative, no. (%), n = 401 (77%) OR (95% CI) p value
Sex
M 261 (50) 53 (44) 208 (52) 0.73 (0.49–1.10) 0.14
F
 260 (50)
 67 (56)
 193 (48)
 Referent
Sign/symptom
Fever 431 (83) 95 (79) 336 (84) 0.74 (0.44–1.25) 0.24
Headache 268 (51) 54 (45) 214 (53) 0.71 (0.47–1.08) 0.11
Breathlessness 84 (16) 16 (13) 68 (17) 0.75 (0.41–1.33) 0.35
Bone/muscle pain 201 (39) 43 (36) 158 (39) 0.86 (0.56–1.31) 0.48
Asthenia 333 (64) 77 (64) 256 (64) 1.01 (0.67–1.56) 0.95
Abdominal pain 219 (42) 29 (24) 190 (47) 0.35 (0.22–0.56) <0.001
Hiccups 39 (7.5) 5 (4.2) 34 (8.5) 0.47 (0.16–1.13) 0.12
Any bleeding 77 (15) 36 (30) 41 (10) 3.76 (2.26–6.25) <0.001
GI symptoms
 355 (68)
 73 (61)
 282 (70)
 0.66 (0.43–1.01)
 0.05
Ebola contact <0.001
Yes 218 (42) 104 (87) 114 (28) 31.3 (15.1–76.1)
No known 56 (11) 9 (7.5) 47 (12) 6.57 (2.33–19.2)
No
 247 (47)
 7 (5.8)
 240 (60)
 Referent
Malaria 0.009
Yes 163 (31) 27 (23) 136 (34) 0.42 (0.24–0.73)
Missing† 233 (45) 53 (44) 180 (45) 0.63 (0.39–1.02)
No 125 (24) 40 (33) 85 (21) Referent

*Patient median age (interquartile range) = 7 (3–13) y; OR (95% CI) = 1.00 (0.97–1.04); p = 0.80. Boldface indicates statistical significance. EVD, Ebola virus disease; GI, gastrointestinal; OR, odds ratio. †Missing refers to patients who did not have a rapid diagnostic test completed or results not available.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

3Current affiliation: Pediatric Infectious Diseases & Immunology, Connecticut Children’s Medical Center, Hartford, Connecticut, USA.

Page created: April 11, 2022
Page updated: May 22, 2022
Page reviewed: May 22, 2022
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