Volume 28, Number 6—June 2022
Research
Risk Prediction Score for Pediatric Patients with Suspected Ebola Virus Disease
Table 3
Performance measures of Pediatric Ebola Risk Score at different cut points and WHO criteria in West Africa cohort, September 2014 – September 2015
Measure |
Measure, % (95% CI) |
|||||
Sensitivity |
Specificity |
PPV |
NPV |
LR+ |
LR– |
|
Score | ||||||
>0 | 98.3 (94.1–99.8) | 26.2 (21.9–30.8) | 28.5 (24.2–33.1) | 98.1 (93.4–99.8) | 1.33 (1.25–1.42) | 0.06 (0.02–0.25) |
>1 | 95.8 (90.5–98.6) | 52.4 (47.3–57.3) | 37.6 (32.1–43.3) | 97.7 (94.7–99.2) | 2.01 (1.8–2.24) | 0.08 (0.03–0.19) |
>2 | 94.2 (88.4–97.6) | 60.1 (55.1–64.9) | 41.4 (35.5–47.5) | 97.2 (94.3–98.9) | 2.36 (2.08–2.68) | 0.10 (0.05–0.2) |
>3 | 79.2 (70.8–86.0) | 81.8 (77.7–85.4) | 56.6 (48.7–64.2) | 92.9 (89.7–95.4) | 4.35 (3.47–5.46) | 0.25 (0.18–0.36) |
>4 |
26.7 (19.0–35.5) |
98.0 (96.1–99.1) |
80.0 (64.4–90.9) |
81.7 (78.0–85.1) |
13.4 (6.33–28.2) |
0.75 (0.67–0.83) |
WHO criteria | 83.3 (75.4–89.5) | 28.9 (24.5–33.6) | 26.0 (21.7–30.7) | 85.3 (78.2–90.8) | 1.17 (1.06–1.30) | 0.58 (0.38–0.88) |
*LR+, true positive/false positive likelihood ratio; LR–, false negative/true negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; WHO, World Health Organization.
1These authors contributed equally to this article.
2These authors contributed equally to this article.
3Current affiliation: Pediatric Infectious Diseases & Immunology, Connecticut Children’s Medical Center, Hartford, Connecticut, USA.