Volume 29, Number 1—January 2023
Research
Seroepidemiology and Carriage of Diphtheria in Epidemic-Prone Area and Implications for Vaccination Policy, Vietnam
Noriko Kitamura
, Thanh T. Hoan, Hung M. Do, The A. Dao, Lien T. Le, Thao T.T. Le, Thuy T.T. Doan, Thuong N. Chau, Hoi T. Dinh, Masaaki Iwaki, Mitsutoshi Senoh, Androulla Efstraciou, Nen M. Ho, Duc M. Pham, Duc-Anh Dang, Michiko Toizumi, Paul Fine, Hung T. Do, and Lay-Myint Yoshida
, Thanh T. Hoan, Hung M. Do, The A. Dao, Lien T. Le, Thao T.T. Le, Thuy T.T. Doan, Thuong N. Chau, Hoi T. Dinh, Masaaki Iwaki, Mitsutoshi Senoh, Androulla Efstraciou, Nen M. Ho, Duc M. Pham, Duc-Anh Dang, Michiko Toizumi, Paul Fine, Hung T. Do, and Lay-Myint Yoshida
Table 3
Geographical distribution, characteristics, and vaccination history of 27 carriers of Corynebacterium diphtheriae, Vietnam*
| Patient no. | District | Commune | Village | HH ID no. | Age, y/sex | tox gene | Biovar | Elek test result | Vaccine status, no. doses | DTP3 coverage, % (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tay Tra |
Tra Phong | Tra Nga | 305 | 25/M | ‒ | gravis | ‒ | NA | 60 (35‒81) |
| 2 | Tra Thanh | Thon Mon | 818 | 23/M | ‒ | NA | NA | NA | 76 (1‒91) | |
| 3† | Tra Lanh | Tra Luong | 1003 | 40/F | ‒ | mitis | ‒ | NA | 64 (34‒86) | |
| 4 | Tra Xinh |
Tra Kem | 1401 | 5/F | ‒ | NA | NA | 4 | 85 (55‒96) | |
| 5 | 1404 | 2/F | ‒ | NA | NA | 4 | ||||
| 6 | 1407 | 4/F | ‒ | NA | NA | 4 | ||||
| 7 | Tra Veo |
1501 | 3/F | ‒ | mitis | ‒ | 4 | 63 (38‒82) |
||
| 8 | 5/F | ‒ | mitis | ‒ | 4 | |||||
| 9 |
1505 |
2/F |
+ |
mitis |
‒ |
4 |
||||
| 10 | Son Ha | Son Ha | Deo Ron | 1607 | 10/F | + | NA | NA | 0 | 71 (44‒89) |
| 11 | 3/F | ‒ | mitis | ‒ | 3 | |||||
| 12 | 2/F | + | NA | NA | 4 | |||||
| 13 | Dong Reng | 1704 | 9/M | ‒ | NA | NA | 0 | 40 (19‒65) | ||
| 14 | 1707 | 14/M | + | mitis | + | NA | ||||
| 15 | Ha Bac | 1807 | 9/M | + | NA | NA | 0 | 71 (46‒87) | ||
| 16 | 1811 | 7/F | + | mitis | + | 4 | ||||
| 17 | 10/M | + | mitis | ‒ | 3 | |||||
| 18 | 1812 | 10/M | + | mitis | ‒ | 3 | ||||
| 19 | 4/M | ‒ | mitis | ‒ | 0 | |||||
| 20 | Son Giang | Lang Ri | 2314 | 10/F | ‒ | mitis | ‒ | 0 | 94 (68‒99) | |
| 21 | Ta Dinh | 2406 | 28/M | ‒ | gravis | ‒ | NA | 93 (63‒99) | ||
| 22 | 25/F | + | gravis | + | NA | |||||
| 23 | 2409 | 3/M | ‒ | gravis | ‒ | 4 | ||||
| 24 | Son Ky | Lang Re | 2505 | 7/F | ‒ | NA | NA | 4 | 88 (61‒97) | |
| 25 | Son Hai | Lang Trang | 3004 | 7/F | ‒ | gravis | ‒ | 3 | 80 (57‒92) | |
| 26 | 3011 | 2/F | ‒ | NA | NA | 3 | ||||
| 27 | 3012 | 5/F | ‒ | gravis | ‒ | 3 |
*DTP3 coverage was the coverage at the village level where carriers were living. DTP, diphtheria‒tetanus‒pertussis; HH, household; ID, identification; NA, not available; ‒, negative; +, positive. †For patient 3, C.diphtheriae was identified from a nasopharyngeal swab specimen and a throat swab specimen. Others were identified only from nasopharyngeal swab specimens.
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