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Volume 29, Number 1—January 2023
Research

Seroepidemiology and Carriage of Diphtheria in Epidemic-Prone Area and Implications for Vaccination Policy, Vietnam

Noriko KitamuraComments to Author , Thanh T. Hoan, Hung M. Do, The A. Dao, Lien T. Le, Thao T.T. Le, Thuy T.T. Doan, Thuong N. Chau, Hoi T. Dinh, Masaaki Iwaki, Mitsutoshi Senoh, Androulla Efstraciou, Nen M. Ho, Duc M. Pham, Duc-Anh Dang, Michiko Toizumi, Paul Fine, Hung T. Do, and Lay-Myint Yoshida
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (N. Kitamura, P. Fine); Nagasaki University, Nagasaki, Japan (N. Kitamura, M. Toizumi, L.-M. Yoshida); Pasteur Institute in Nha Trang, Nha Trang, Vietnam (T.T. Hoan, H.M. Do, T.A. Dao, L.T. Le, T.T.T. Le, T.T.T. Doan, H.T. Do); Quang Ngai Provincial Health Services, Quang Ngai, Vietnam (T.N. Chau, H.T. Dinh, N.M. Ho, D.M. Pham); National Institute of Infectious Diseases, Tokyo, Japan (M. Iwaki, M. Senoh); National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (D.-A. Dang); UK Health Security Agency, London (A. Efstraciou)

Main Article

Table 2

Age-stratified carriage prevalence of Corynebacterium diphtheriae and seroprevalence of diphtheria toxoid IgG () in 2 districts, Quang Ngai Province, Vietnam*

Group Mean ± SD age, y Total. Seroprevalence, No. (%) 95% CI Carriage prevalence, No. (%) 95% CI
Age group, y
<5 3.2 ± 1.36 269 108 (39.5) 22.7‒59.2 12 (4.50) 3.7‒5.5
6‒17 10.1 ± 3.17 332 120 (36.7) 29.4‒44.6 10 (2.5) 0.1‒47.5
18‒40 29.5 ± 5.61 513 283 (55.3) 42.8‒67.1 5 (1.0) 0.6‒1.7
41‒55 46.3 ± 4.30 102 64 (62.9) 60.9‒64.8 0 (0) NA
Total
20.0 ± 14.3
1,216
575 (51.4) 3.6‒59.1

27 (1.4) 0.4‒5.4
District
Tay Tra, by age group, y
<5 3.1 ± 1.42 125 41 (32.8) 25.1‒41.5 6 (4.8) 2.2‒10.3
6‒17 9.9 ± 3.09 171 59 (34.5) 27.8‒41.9 0 (0) NA
18‒40 29.7 ± 5.19 258 152 (58.9) 52.8‒64.8 3 (1.2) 0.4‒3.5)
41‒55 46.4 ± 4.69 50 31 (62.0) 47.9‒74.3 0 (0) NA
Total 20.0 ± 14.2 604 283 (50.6) 33.6‒67.5 9 (0.9) 0.2‒3.7
Son Ha, by age group, y
<5 3.2 ± 1.31 144 67 (46.5) 38.5‒54.7 6 (4.2) 1.9‒9.0
6‒17 10.4 ± 3.25 151 61 (40.4) 32.9‒48.4 10 (6.6) 3.6‒11.9
18‒40 29.4 ± 6.04 265 131 (49.4) 43.4‒55.4 2 (0.8) 0.2‒0.3
41‒55 46.2 ± 3.94 52 33 (63.5) 49.7‒75.3 0 (0) NA
Total 20.0 ± 14.4 612 292 (52.4) 39.1‒65.3) 18 (2.0) 0.3‒11.0

*Seroprevalence and carriage prevalence were weighted for overall groups. IgG cutoff >0.1 IU/mL. NA, not applicable.

Main Article

Page created: November 01, 2022
Page updated: December 21, 2022
Page reviewed: December 21, 2022
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