Volume 31, Number 3—March 2025
Research
High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia
Danila Zimenkov
, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
Table 1
Clinical characteristics of TB cases and resistance to bedaquiline and linezolid determined by phenotypic and genotypic methods in study of high prevalence of atpE mutations in bedaquiline-resistant Mycobacterium tuberculosis isolates, Russia*
| Category | Isolate identification |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9c | |
| Year of TB diagnosis |
2017 |
2006 |
2015 |
2010 |
2018 |
2017 |
2017 |
2012 |
2007 |
| HIV status |
Yes |
No |
No |
No |
Yes |
No |
No |
Yes |
No |
| Source of the culture |
Sputum |
Surgery |
Sputum |
Wound exudate |
Sputum |
Sputum |
Wound exudate |
Sputum |
Sputum |
| No. days from treatment start |
92 |
718 |
196 |
1,045 |
206 |
558 |
866 |
609 |
1,154 |
| Treatment outcome |
Treatment failed |
Not evaluated |
Treatment failed |
Death from TB |
Death from TB |
Treatment failed |
Treatment failed |
Treatment failed |
Treatment failed |
| Sublineage |
B0 |
B0 |
B0 |
CA/R |
B0 |
B0 |
B0 |
B0 |
B0 |
| Bedaquiline phenotype |
R |
R |
R |
S |
R |
R |
R |
R |
R |
| AtpE Glu61Asp, g>t | 100% | ||||||||
| AtpE Glu61Asp, g>c | 59% | ||||||||
| AtpE Ile66Met |
100% |
100% |
|||||||
| MmpR5 Cys46fs | 21% | ||||||||
| MmpR5 Asp47fs | 52% | ||||||||
| MmpR5 Glu49fs | 42% | 97% | |||||||
| MmpR5 Ser63Gly | 75% | ||||||||
| MmpR5 Ile67fs | 97% | 96% | |||||||
| MmpR5 Gln76stop | 28% | ||||||||
| MmpR5 Leu143_ Glu147dup |
22% |
||||||||
| MmpL4 Leu130fs† |
91% |
||||||||
| MmpL5 Asn772Thr† |
37% |
||||||||
| AtpB Val165Leu† |
100% |
||||||||
| Linezolid phenotype |
S |
S |
S |
R |
S |
S |
S |
R |
R |
| RplC Cys154Arg | 100% | 100% | 100% | ||||||
*Percentages indicate relative number of reads with mutations. ID, identification; R, resistant; S, susceptible; TB, tuberculosis. †Mutations in candidate genes associated with resistance to bedaquiline.
Page created: January 06, 2025
Page updated: February 28, 2025
Page reviewed: February 28, 2025
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