Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 31, Number 3—March 2025
Research
High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia
Danila Zimenkov
, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
Table 1
Clinical characteristics of TB cases and resistance to bedaquiline and linezolid determined by phenotypic and genotypic methods in study of high prevalence of atpE mutations in bedaquiline-resistant Mycobacterium tuberculosis isolates, Russia*
| Category | Isolate identification |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9c | |
| Year of TB diagnosis | 2017 | 2006 | 2015 | 2010 | 2018 | 2017 | 2017 | 2012 | 2007 |
| HIV status | Yes | No | No | No | Yes | No | No | Yes | No |
| Source of the culture | Sputum | Surgery | Sputum | Wound exudate | Sputum | Sputum | Wound exudate | Sputum | Sputum |
| No. days from treatment start | 92 | 718 | 196 | 1,045 | 206 | 558 | 866 | 609 | 1,154 |
| Treatment outcome | Treatment failed | Not evaluated | Treatment failed | Death from TB | Death from TB | Treatment failed | Treatment failed | Treatment failed | Treatment failed |
| Sublineage | B0 | B0 | B0 | CA/R | B0 | B0 | B0 | B0 | B0 |
| Bedaquiline phenotype | R | R | R | S | R | R | R | R | R |
| AtpE Glu61DAsp, g>t | 100% | ||||||||
| AtpE Glu61Asp, g>c | 59% | ||||||||
| AtpE Ile66Met | 100% | 100% | |||||||
| MmpR5 Cys46fs | 21% | ||||||||
| MmpR5 Asp47fs | 52% | ||||||||
| MmpR5 Glu49fs | 42% | 97% | |||||||
| MmpR5 Ser63Gly | 75% | ||||||||
| MmpR5 Ile67fs | 97% | 96% | |||||||
| MmpR5 Gln76stop | 28% | ||||||||
| MmpR5 Leu143_Glu147dup | 22% | ||||||||
| MmpL4 Leu130fs† | 91% | ||||||||
| MmpL5 Asn772Thr† | 37% | ||||||||
| AtpB Val165Leu† | 100% | ||||||||
| Linezolid phenotype | S | S | S | R | S | S | S | R | R |
| RplC Cys154Arg | 100% | 100% | 100% | ||||||
*Percentages indicate relative number of reads with mutations. ID, identification; R, resistant; S, susceptible; TB, tuberculosis. †Mutations in candidate genes associated with resistance to bedaquiline.
Page created: January 06, 2025
Page updated: February 21, 2025
Page reviewed: February 21, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.