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Volume 31, Number 3—March 2025
Research

High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia

Danila ZimenkovComments to Author , Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
Author affiliation: Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia (D. Zimenkov, A. Ushtanit); Federal State Budgetary Institution Novosibirsk TB Research Institute, Ministry of Health, Novosibirsk, Russia (E. Gordeeva, E. Guselnikova, Y. Schwartz, N. Stavitskaya)

Main Article

Figure 1

Mapping of the candidate substitution Asn722Thr on the atomic model of Mycobacterium smegmatis MmpL5 transporter (PDB: 9B46) in study of high prevalence of atpE mutations in bedaquiline-resistant M. tuberculosis isolates, Russia. The proposed channel inlet is indicated on the surface model of the MmpL5. The channel model (olive) is shown on the cartoon model of the MmpL5 fragment. Red coloring and text indicates Ala774, located in the transmembrane domain TM8. Green text indicates residues and numbering for M. tuberculosis.

Figure 1. Mapping of the candidate substitution Asn722Thr on the atomic model of Mycobacterium smegmatis MmpL5 transporter (PDB: 9B46) in study of high prevalence of atpE mutations in bedaquiline-resistant M. tuberculosis isolates, Russia. The proposed channel inlet is indicated on the surface model of the MmpL5. The channel model (olive) is shown on the cartoon model of the MmpL5 fragment. Red coloring and text indicates Ala774, located in the transmembrane domain TM8. Green text indicates residues and numbering for M. tuberculosis.

Main Article

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Page updated: February 28, 2025
Page reviewed: February 28, 2025
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