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Volume 31, Number 3—March 2025
Research

High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia

Danila ZimenkovComments to Author , Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
Author affiliation: Author affiliations: Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia (D. Zimenkov, A. Ushtanit); Federal State Budgetary Institution Novosibirsk TB Research Institute, Ministry of Health, Novosibirsk, Russia (E. Gordeeva, E. Guselnikova, Y. Schwartz, N. Stavitskaya)

Main Article

Table 2

Allele frequencies change in sequential isolates from patient #9 during treatment in study of high prevalence of atpE mutations in bedaquiline-resistant Mycobacterium tuberculosis isolates, Russia

Gene or intergenic region Amino acid substitution Isolate 9a, day 1,004 Isolate 9b, day 1,037 Isolate 9c, day 1,154 Associated with resistance
atpE
 Glu61Asp
59%
 Bedaquiline
mmpR5 (Rv0678) Ile67fs 18% 15% 96% Bedaquiline
Leu143*
 80%
 63%
mmpL5 Asn772Thr 37% Bedaquiline
alr Glu6Gln 78% 65% D-cycloserine
gabD2 Val153fs 39% D-cycloserine
Rv2690c Gly191Arg 26% (Pyrazinamide)
pncA Met1Thr 100% 100% 100% Pyrazinamide
ceoC Ala130Thr 25% (Isoniazid)
PPE8 Asp1235fs 64% 63%
PPE35 Leu939fs 18% 96%
Rv2298 Gly16Glu 23%
moeW-mmpL9 71% 64%
sigL Leu120Leu 63%
purM Pro290Pro 22%
Rv3083 Leu439Leu 6% 22%

Main Article

Page created: January 06, 2025
Page updated: February 21, 2025
Page reviewed: February 21, 2025
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