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Volume 31, Number 3—March 2025
Research

High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia

Danila ZimenkovComments to Author , Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, and Natalia Stavitskaya
Author affiliation: Author affiliations: Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia (D. Zimenkov, A. Ushtanit); Federal State Budgetary Institution Novosibirsk TB Research Institute, Ministry of Health, Novosibirsk, Russia (E. Gordeeva, E. Guselnikova, Y. Schwartz, N. Stavitskaya)

Main Article

Table 4

Bedaquiline MIC values for isolates from the CRyPTIC study with mutation in atpB gene in study of high prevalence of atpE mutations in bedaquiline-resistant Mycobacterium tuberculosis isolates, Russia

Isolates
 Bedaquiline MIC, mg/L
<0.008
 <0.015
 0.015
 0.03
 0.06
 0.12
 0.25
 0.5
 1
 >1
 2
 >2
All isolates 337 1199 851 3405 3082 603 194 54 26 5 3 5
AtpB (Thr166Met) 3 8 4 3

Main Article

Page created: January 06, 2025
Page updated: February 21, 2025
Page reviewed: February 21, 2025
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