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Volume 31, Number 4—April 2025
Research

Case–Control Study of Factors Associated with Hemolytic Uremic Syndrome among Shiga Toxin–Producing Escherichia coli Patients, Ireland, 2017–2020

Diana Espadinha1Comments to Author , Melissa Brady1Comments to Author , Carina Brehony, Douglas Hamilton, Lois O’Connor, Robert Cunney, Suzanne Cotter, Anne Carroll, Patricia Garvey, and Eleanor McNamara
Author affiliation: European Programme for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Solna, Sweden (D. Espadinha); National Reference Laboratory for STEC at Public Health Laboratory Health Service Executive, Cherry Orchard Hospital, Dublin, Ireland (D. Espadinha, A. Carroll, E. McNamara); European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Solna (M. Brady); Health Service Executive Health Protection Surveillance Centre, Dublin (M. Brady, C. Brehony, S. Cotter, P. Garvey); Health Service Executive National Social Inclusion Office, Dublin (D. Hamilton); Health Service Executive Public Health, Dr. Steevens’ Hospital, Dublin (L. O'Connor); Children's Health Ireland at Temple Street, Dublin (R. Cunney); Royal College of Surgeons in Ireland, Dublin (R. Cunney); Trinity College Dublin School of Medicine and Saint James's Hospital, Dublin (E. McNamara)

Main Article

Table 4

Genes with positive association with HUS after genomewide association analysis in study of HUS development among persons with STEC, Ireland, 2017–2020*

Gene annotation Functional annotation OR†
stx2B Shiga toxin 2 subunit B 6.4
ybcQ_1 DLP12 prophage; predicted antitermination protein 5.4
group_31760 Hypothetical protein 4.4
ydfU_1 Qin prophage; predicted protein 4.3
group_30198 Hypothetical protein 4.4
group_31748 Hypothetical protein 4.7
group_30187 Hypothetical protein 5.0
group_5720/mokC_2‡ Regulatory peptide whose translation enables hokC (gef) expression 2.8
sodA Superoxide dismutase (Mn) 2.6
pfkA 6-phosphofructokinase-1 monomer 2.6
group_33058 Hypothetical protein 2.5
fieF Zn2+/Fe2+/Cd2+ efflux transporter FieF 2.5
group_36684 Hypothetical protein 2.5
yiaU Putative DNA binding transcriptional regulator, LysR-type 4.6
tpiA Triose phosphate isomerase monomer 2.5
uspD Stress protein involved in resistance to UV irradiation 2.4
group_20906 Adenine:H+ symporter 2.4
group_31570 Hypothetical protein 2.4
cpxP Regulator of the Cpx response and possible chaperone involved in resistance to extracytoplasmic stress 2.4
group_34824 Putative DNA binding response regulator in 2-component system with YedV 2.4
sbp Sulfate/thiosulfate ABC transporter – periplasmic binding protein Sbp 2.4
cpxA Sensor histidine kinase CpxA 2.4
yiiM Protein involved in base analog detoxification 2.3
cdh CDP-diglyceride hydrolase/CDP-diacylglycerol pyrophosphatase 2.3
ygiW_2 Stress-induced protein 2.6
rsxG Member of SoxR-reducing complex 4.0

*N = 524 patients. HUS, hemolytic uremic syndrome; OR, odds ratio; STEC, Shiga toxin–producing Escherichia coli. †OR >1, Benjamini-Hochberg p<0.05, pairwise comparisons p<0.05. ‡Nonunique gene name where sequences with the same gene name have ended up in different groups. It might be because of split genes or misannotation.

Main Article

1These authors were co–principal investigators, contributed equally to this work, and share first authorship.

Page created: February 28, 2025
Page updated: March 24, 2025
Page reviewed: March 24, 2025
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