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Emergence of Novel Macrolide-Resistant Mycoplasma pneumoniae Sequence Type 3 Subclades in Children after COVID-19 Pandemic, Taiwan
Yu-Chia Hsieh, Chen-Ching Lin, Jia-Wen Wu, Yi-Hsuan Liu, Yi-Jiun Pan, Tzu-Ya Lo, Shian-Sen Shie, Huey-Ling You, Chong-Wei Huang, Yi-Chuan Huang, Tzu-Ching Huang, Yu-Xin She, Yin-Cheng Chen
1, and Shiao-Wen Li
1
Author affiliation: Chang Gung Children’s Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan (Y.-C. Hsieh, J.-W. Wu, Y.-H. Liu, T.-Y. Lo); School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (C.-C. Lin, Y.-C. Chen); School of Medicine, College of Medicine, People’s Republic of China Medical University, Taichung, Taiwan (Y.-J. Pan); Chang Gung Memorial Hospital, Taoyuan (S.-S. Shie); Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan (H.-L. You); Keelung Chang Gung Memorial Hospital, Keelung, Taiwan (C.-W. Huang, Y.-C. Huang); School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei (T.-C. Huang); College of Science Department of Life Sciences, National University of Kaohsiung, Kaohsiung (Y.-X. She, S.-W. Li)
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Figure 4
Figure 4. Temporal prevalence of Mycoplasma pneumoniae in study of emergence of novel macrolide-resistant M. pneumoniae sequence type 3 subclades in children after COVID-19 pandemic, Taiwan, 2017–2024. A) Temporal signal in ST3 genomes evaluated by linear regression of root-to-tip genetic distances against sampling year for global isolates collected during 1960–2024, indicating molecular clock consistency. B) Temporal prevalence of ST3 subclades among persons <18 years of age, Taiwan, 2018–2024. Isolates collected in 2024 are shown at quarterly intervals. ST, sequence type.
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