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Detection of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Genotype D1.2 Virus in Swine after Experimental Inoculation
Hannah Seger, Amy L. Baker, Alexandra C. Buckley, Tavis K. Anderson, Alexey Markin, Alessandra Campos, Bruno Caetano Trindade, Marissa Vincent, Giovana Ciacci Zanella, Mia Torchetti, Kristina Lantz, and Bailey Arruda
Author affiliation: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (H. Seger); US Department of Agriculture Agricultural Research Service National Animal Disease Center, Ames, Iowa, USA (H. Seger, A.L. Baker, A.C. Buckley, T.K. Anderson, A. Markin, A. Campos, B.C. Trindade, M. Vincent, G.C. Zanella, B. Arruda); Iowa State University College of Veterinary Medicine, Ames (G.C. Zanella); US Department of Agriculture Animal and Plant Health Inspection Service National Veterinary Services Laboratories, Ames (M. Torchetti, K. Lantz)
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Figure 3
Figure 3. Distribution of influenza A virus nucleoprotein (NP) antigen in the ethmoids of pigs in study of systemic distribution and protracted detection of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b genotype D1.2 virus in swine after experimental inoculation. At 5 days postinoculation, NP antigen (brown) was detected within the epithelial layer in areas of erosion (brace) and fila olfactoria (panel A, arrowheads; animal no. 641; original magnification ×200) and without (panel B; animal no. 647; original magnification ×200) notable loss of cilia of the ethmoid. Immunolabeling was detected in cells with morphologies consistent with olfactory sensory neurons (panel C; animal no. 642; original magnification ×400) and, rarely, the epithelium of Bowman’s gland (panel D; animal no. 642; original magnification ×400).
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