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Volume 20, Number 5—May 2014
Research

Bovine Leukemia Virus DNA in Human Breast Tissue

Gertrude Case BuehringComments to Author , Hua Min Shen, Hanne M. Jensen, K. Yeon Choi1, Dejun Sun, and Gerard Nuovo
Author affiliations: University of California, Berkeley, California, USA (G.C. Buehring, H.M. Shen, K.Y. Choi, D. Sun); University of California Davis Medical Center, Sacramento, California, USA (H.M. Jensen); Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA (G. Nuovo)

Main Article

Table 5

PCR results for detection of BLV in breast tissue samples from 6 women*

Sample code Sample pathology Patient age, y BLV genome regions
L-PCR
 IS-PCR
LTR gag pol env tax tax
143 Malignant 63 – – – – – –
0253 Malignant 47 + – – – + +
010 Malignant 48 + – – – + +
236 Nonmalignant 54 + + – + + +
23803 Nonmalignant 50 + + – + + +
20874 Nonmalignant 53 + + + + + +

*BLV, bovine leukemia virus; L-PCR, nested liquid-phase PCR; IS-PCR, nested in situ PCR; LTR, long terminal repeat (promoter region); gag, group-specific antigen (capsid region); pol, polymerase (reverse transcription); env, envelope; tax, transactivating region of the X gene.

Main Article

1Current affiliation: Texas A&M Health Science Center College of Medicine, College Station, Texas, USA.

Page created: April 16, 2014
Page updated: April 16, 2014
Page reviewed: April 16, 2014
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