African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004–2014
Camilla Weyer, John D. Grewar, Phillippa Burger, Esthea Rossouw, Carina Lourens, Christopher Joone, Misha le Grange, Peter Coetzee, Estelle H. Venter, Darren P. Martin, N. James MacLachlan, and Alan J. Guthrie
Author affiliations: University of Pretoria, Onderstepoort, South Africa (C.T. Weyer, P. Burger, C. Lourens, C. Joone, M. le Grange, P. Coetzee, E. Venter, N.J. MacLachlan, A.J. Guthrie); Western Cape Department of Agriculture, Elsenburg, South Africa (J.D. Grewar); Wits Health Consortium, Johannesburg, South Africa (E. Rossouw); University of Cape Town, Cape Town, South Africa (D.P. Martin); University of California, Davis, CA, USA (N.J. MacLachlan)
Figure 2. Whole-genome phylogeny of African horse sickness (AHS) viruses identified in AHS outbreaks in Western Cape Province, South Africa, 2004–2014. Maximum-likelihood phylogenetic tree indicating the genetic relationships of concatenated whole genome nucleotide sequences of AHS viruses from affected horses in the 2004, 2011, and 2014 outbreaks in the AHS controlled area in Western Cape Province to the AHS live, attenuated vaccine viruses and reference viruses. Branches are scaled to represent numbers of inferred nucleotide differences per site. Branches supported by full maximum-likelihood bootstrap values >70% are indicated. Genotype groups are indicated at right. Scale bar indicates genetic distance.
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