Volume 22, Number 12—December 2016
Research
African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004–2014
Table 1
Attenuation-associated nonsynonymous SNVs of consensus sequences of genome segments of AHSV-1 viruses from 4 AHS outbreaks in the AHS controlled area of Western Cape Province, South Africa, 2004–2014, and reference strains*
Abbreviated strain name |
Genome segment and amino acid position |
Genotype group |
||||||
---|---|---|---|---|---|---|---|---|
VP2 357 |
VP3 232 |
VP5 422 |
VP5 434 |
VP6 81 |
VP6 169 |
NS3 201 |
||
1/E.cab-tc/ZAF/62/OVI-HS29/62 | N | Y | S | T | A | R | M | |
1/Lab/ZAF/98/OBP-116† | K | H | N | I | V | Q | K | |
1/E.cab-tc/ZAF/04/Elb-E040019 | ‡ | T§ | A | R | E | 1a | ||
1/E.cab-tc/ZAF/04/Elb-E040020 | T | A | R | E | 1a | |||
1/E.cab-tc/ZAF/04/Elb-E040021 | T | A | R | E | 1a | |||
1/E.cab-tc/ZAF/04/Dkt-E040029 | T | A | R | E | 1a | |||
1/E.cab-tc/ZAF/04/Tgd-E040031 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Elb-E040034 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Tgd-E040039 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Avt-E040043 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Avt-E040048 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Vdm-E040062 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Tgd-E040064 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Vdm-E040065 | N | T | A | ¶ | 1b | |||
1/E.cab-tc/ZAF/04/Avt-E040066 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Avt-E040081 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Kbk-E040086 | N | T | A | R | ¶ | 1b | ||
1/E.cab-tc/ZAF/04/Avt-E040061 | N | ¶ | ¶ | A | R | ¶ | 1c | |
1/E.cab-tc/ZAF/11/Mre-E110143_1 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110180_WC44 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110180_WC61 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110180_WC165 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110411_1 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110418_1 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/11/Mre-E110674_3 | T | A | R | N | 2 | |||
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00522 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00528 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00533 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00544 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00555 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00481 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00482 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00488 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00491 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00493 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Srn-E140526_WC00502 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00506 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00507 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00508 | T | A | R | ¶ | 3a | |||
1/E.cab-tc/ZAF/14/Rbn-E140702_RB00008 | T | A | R | ¶ | 3b | |||
1/E.cab-tc/ZAF/14/Rbn-E140816_RB00221 | T | A | R | ¶ | 3b |
*AHS, African horse sickness; AHSV-1, AHS virus type 1; NS3, nonstructural protein 3; SNV, single-nucleotide variants; VP, viral protein.
†The changes in amino acids are indicated in comparison with the AHSV-1 live, attenuated vaccine-derived strain (1/Lab/ZAF/98/OBP-116) for relevant viral proteins.
‡Sequences that were identical to the consensus sequence of the vaccine-derived strain are indicated by an empty cell.
§Sequences that differed from the consensus sequence of the AHSV-1 live, attenuated vaccine-derived strain are indicated with the letter symbol of the relevant amino acid.
¶Indicates that these segments were not considered due to a recombination event that occurred with another vaccine-derived AHSV type.