Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006–2009
Macarthur Charles, Sanchita Das, Rachel Daniels, Laura Kirkman, Glavdia G. Delva, Rodney Destine, Ananias A. Escalante, Leopoldo Villegas, Noah M. Daniels, Kristi Shigyo, Sarah K. Volkman, Jean W. Pape, and Linnie M. Golightly
Author affiliations: Weill Medical College of Cornell University, New York, New York, USA (M. Charles, S. Das, L. Kirkman, K. Shigyo, J.W. Pape, L.M. Golightly); The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections Centers (GHESKIO); Port-au-Prince, Haiti (M. Charles, G.G. Delva, R. Destine, J.W. Pape); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Daniels, S.K. Volkman); Broad Institute, Cambridge, Massachusetts, USA (R. Daniels, S.K. Volkman); Temple University, Department of Biology, Philadelphia, Pennsylvania, USA (A. Escalante); ICF International, Rockville, Maryland, USA (L. Villegas); Centro de Investigación de Campo Dr. Francesco Vitanza, Tumeremo, Venezuela (L. Villegas); Massachusetts Institute of Technology, Cambridge (N.M. Daniels); Simmons College, Boston (S.K. Volkman)
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Figure 3
Figure 3. Visualization of 15 identical (same single-nucleotide polymorphism positions call at 24 of 24 positions) and nearly identical (23 of 24 identical positions) molecular barcodes from 42 monogenomic samples from patients in Haiti, 2006 and 2007. Each node (oval) represents an individual barcode. Samples with identical barcodes are included in the same nodes, and related barcodes (1 single-nucleotide polymorphism positions difference) are connected by lines. Gray nodes indicate that there is some point of ambiguity between barcodes, defined as either both alleles detected (N) or no data (X) at a specific position, indicating <100% confidence of a complete match between barcodes.
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