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Volume 22, Number 5—May 2016
Research

Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006–2009

Macarthur Charles, Sanchita Das, Rachel Daniels, Laura Kirkman, Glavdia G. Delva, Rodney Destine, Ananias A. Escalante, Leopoldo Villegas, Noah M. Daniels, Kristi Shigyo, Sarah K. Volkman, Jean W. Pape, and Linnie M. GolightlyComments to Author 
Author affiliations: Weill Medical College of Cornell University, New York, New York, USA (M. Charles, S. Das, L. Kirkman, K. Shigyo, J.W. Pape, L.M. Golightly); The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections Centers (GHESKIO); Port-au-Prince, Haiti (M. Charles, G.G. Delva, R. Destine, J.W. Pape); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Daniels, S.K. Volkman); Broad Institute, Cambridge, Massachusetts, USA (R. Daniels, S.K. Volkman); Temple University, Department of Biology, Philadelphia, Pennsylvania, USA (A. Escalante); ICF International, Rockville, Maryland, USA (L. Villegas); Centro de Investigación de Campo Dr. Francesco Vitanza, Tumeremo, Venezuela (L. Villegas); Massachusetts Institute of Technology, Cambridge (N.M. Daniels); Simmons College, Boston (S.K. Volkman)

Main Article

Table 2

Monogenic barcoding data of Plasmodium falciparum samples determined to assess genetic relatedness, Haiti, 2006 and 2007

Sample Location Year Molecular barcode* Type Category
15 Deschappelles 2006 TACTGCGGATTACCACCAAACTTG A Identical
35
 Les Cayes
 2007
 TACTGCGGATTACCACCAAACTTG
Identical
22 Jeremie 2007 CACTCCGGATCXTCAACAAACTTG B Identical
23
 Jeremie
 2007
 CACTCCGGATCXTCAACAAACTTG
Identical
31 Les Cayes 2007 TACTGGGGACTACACCCTAGCTTG C Identical
33
 Les Cayes
 2007
 TACTGGGGACTACACCCTAGCTTG
Identical
38 Les Cayes 2007 TACTCCGGATCGTCCACAAGCTTG D Identical
44 Les Cayes 2007 TACTCCGGATCGTCCACAAGCTTG Identical
27
 Les Cayes
 2007
 TACTCCGGATTXTCCACAAGCTTG
Related
6 Miragoane 2006 TACTCCAGACTXCCAACTCGATTG E Related
36
 Les Cayes
 2007
 TACTCCAGACTACCAACTCGATTG
Related
11 Deschappelles 2006 TATCCCGGATTACCACCTAACCTG F Related
16
 Deschappelles
 2007
 TATCCCGGATTAXCCCCTAACCTG
Related
30 Les Cayes 2007 TACTGCGGATXACACACTAGCCTG G Related
43
 Les Cayes
 2007
 TACTGCGGATTXCACACAAGCCTX
Related
5 Miragoane 2006 XACTCCGGACTXCAACCAAACTTG U Unique
7 Miragoane 2006 TACTCCAGACTACCAACTCGACGG U Unique
8 Deschappelles 2006 TATTGCGGATTXCCCCCTAACTTG U Unique
9 Deschappelles 2006 CACTCCGGATTACACACAAACCTG U Unique
10 Deschappelles 2006 TATCCCGGATCATACCCTAACTTG U Unique
12 Deschappelles 2006 TACTGCAGATXXCACACTAAACTG U Unique
13 Deschappelles 2006 TATTGCAGATCGTCCCCTAGATTG U Unique
14 Deschappelles 2006 TACTCCAGATTGTCCCCTAGCTTG U Unique
17 Deschappelles 2007 TACTGCGGATCATAACCAAGCTTG U Unique
18 Jacmel 2006 TAXTCCGGATTGTCACCAAGCTTG U Unique
19 Jacmel 2007 TACTGCGGATCATAAACAAACTTG U Unique
20† Jeremie 2007 TACXCXAGATTXTCXXTACACTTG U Unique
21 Jeremie 2007 TATTGCGGATTACACCCTAGCCTG U Unique
24 Cap-Haitien 2006 TXCXCCGGAXTXCCCXCAAGXTTG U Unique
25 Les Cayes 2006 TACTGCAGATCGTACCTTAGCCTG U Unique
26 Les Cayes 2006 TACCCCGGACCGCAACCTAAATTG U Unique
28 Les Cayes 2007 TATTCCAGATCGTCCCTTAGACTG U Unique
29 Les Cayes 2007 TAXTGCGGATTGTCACCTAACTTG U Unique
32 Les Cayes 2007 TACCCCGGATTXCACCCAAACTTG U Unique
34 Les Cayes 2007 TACTCCGGACCGCACCCTAAATTG U Unique
37 Les Cayes 2007 TACTCCGGACTACCCCCTAACTTG U Unique
39 Les Cayes 2007 TATCGCAGATTACCAATAAGCCTG U Unique
41 Les Cayes 2007 TATTCCGGATXACCCACTAGCTTG U Unique
42 Les Cayes 2007 TATTCGGGATTATCCACTAGATTG U Unique
45 Les Cayes 2007 TACXGXAGATTXTCCCCACGCTTG U Unique
46 Les Cayes 2007 TACTGCGGACCGXCCCCTAACCTG U Unique
47
 Les Cayes
 2007
 TACTGCAGACTXCCCCCACGCTTG
 U
 Unique
*X indicates missing data, where neither the major or minor allele could be detected.
†Sample 20 from Jeremie revealed the possible presence of both alleles by mutation-specific restriction–endonuclease digestion and DNA sequencing.

Main Article

Page created: April 13, 2016
Page updated: April 13, 2016
Page reviewed: April 13, 2016
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