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Volume 22, Number 8—August 2016

Research

Virulence and Evolution of West Nile Virus, Australia, 1960–2012

Natalie A. Prow12, Judith H. Edmonds2, David T. Williams, Yin X. Setoh, Helle Bielefeldt-Ohmann, Willy W. Suen, Jody Hobson-Peters, Andrew F. van den Hurk, Alyssa T. Pyke, Sonja Hall-Mendelin, Judith A. Northill, Cheryl A. Johansen, David Warrilow, Jianning Wang, Peter D. Kirkland, Stephen Doggett, Christy C. Andrade3, Aaron C. Brault, Alexander A. Khromykh4Comments to Author , and Roy A. Hall4Comments to Author 
Author affiliations: The University of Queensland, St. Lucia, Queensland, Australia (N.A. Prow, J.H. Edmonds, Y.X. Setoh, H. Bielefeldt-Ohmann, W.W. Suen, J. Hobson-Peters, A.A. Khromykh, R.A. Hall); CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia (D.T. Williams, J. Wang); The University of Queensland, Gatton, Queensland, Australia (H. Bielefeldt-Ohmann, W.W. Suen); Department of Health, Brisbane, Queensland, Australia (A.F. van den Hurk, A.T. Pyke, S. Hall-Mendelin, J.A. Northill, D. Warrilow); The University of Western Australia, Nedlands, Western Australia, Australia (C.A. Johansen); Elizabeth Macarthur Agriculture Institute, Menangle, New South Wales, Australia (P.D. Kirkland); University of Sydney and Pathology West–ICPMR, Westmead, New South Wales, Australia (S. Doggett); University of California, Davis, California, USA (C.C. Andrade, A.C. Brault); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (C.C. Andrade, A.C. Brault)

Main Article

Table 1

WNVKUN strains used during study of virulence and evolution of WNV, Australia, 1960–2012*

Isolate Year collected Location Source Passage history
MRM16/MRM61C† 1960 Mitchell River Mission, Queensland Mosquito‡ Unknown
Boort 1984 Victoria Horse spinal cord Unknown
K2499 1984 Kimberley region, Western Australia Mosquito‡ 2× C6/36; 1× PSEK
Hu6774 1991 New South Wales Human Unknown
K6453 1991 Kimberley region, Western Australia Mosquito‡ 2× C6/36; 1× PSEK
SH183 1991 Victoria Chicken Unknown
Gu0631 2000 Gulf of Carpentaria, Queensland Mosquito‡ 3× C6/36
Gu1009 2000 Gulf of Carpentaria, Queensland Mosquito‡ 3× C6/36
K68967 2009 Kimberley region, Western Australia Mosquito‡ 3× C6/36
P9974 2009 Pilbara region, Western Australia Mosquito‡ 3× C6/36
NSW2011 2011 New South Wales Horse brain 2× C6/36; 1 Vero
K74015 2011 Kimberley region, Western Australia Mosquito‡ 3× C6/36
NSW2012 2012 New South Wales Mosquito‡ 3× C6/36

*C6/36, from Aedes albopictus mosquitoes; PSEK, porcine squamous equine kidney cells; WNV, West Nile virus; WNVKUN, Kunjin strain of WNV.
†Prototype strain.
‡Culex annulirostris.

Main Article

1Current affiliation: QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

2These authors contributed equally to the major technical aspects of the work.

3Current affiliation: Willamette University, Salem, Oregon, USA.

4These authors served as joint senior authors.

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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