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Volume 24, Number 5—May 2018

Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007–2016

Andrew Fox-LewisComments to Author , Junko Takata, Thyl Miliya, Yoel Lubell, Sona Soeng, Poda Sar, Kolthida Rith, Gregor McKellar, Vanaporn Wuthiekanun, Erin McGonagle, Nicole Stoesser, Catrin E. Moore, Christopher M. Parry, Claudia Turner, Nicholas P.J. Day, Ben S. Cooper, and Paul Turner
Author affiliations: University of Oxford, Oxford, UK (A. Fox-Lewis, J. Takata, Y. Lubell, N. Stoesser, C.E. Moore, C. Turner, N.P.J. Day, B.S. Cooper, P. Turner); Angkor Hospital for Children, Siem Reap, Cambodia (A. Fox-Lewis, T. Miliya, S. Soeng, P. Sar, K. Rith, G. McKellar, C. Turner, P. Turner); Cambodia-Oxford Medical Research Unit, Siem Reap (A. Fox-Lewis, T. Miliya, S. Soeng, P. Sar, K. Rith, C. Turner, P. Turner); Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand (Y. Lubell, V. Wuthiekanun, C.E. Moore, N.P.J. Day, B.S. Cooper); University of Colorado, Aurora, Colorado, USA (E. McGonagle); Liverpool School of Tropical Medicine, Liverpool, UK (C.M. Parry); Nagasaki University, Nagasaki, Japan (C.M. Parry)

Main Article

Table 6

Multivariable logistic regression analysis of 129 hospital admission episodes for community-acquired monomicrobial gram-negative bacteremia from children at Angkor Hospital for Children, Siem Reap, Cambodia, 2007–2016*

Predictor variable Death
ICU admission
OR (95% CI) p value OR (95% CI) p value
Third-generation cephalosporin resistance 2.65 (1.05–6.96) 0.042 3.17 (1.31–8.10) 0.013
Neonate† 3.03 (1.14–8.31) 0.028 4.56 (1.83–12.16) 0.002
Male 0.81 (0.32–2.07) 0.659 0.81 (0.35–1.85) 0.616
Enterobacteriaceae 26.25 (4.43–511.1) 0.003 3.07 (1.05–9.67) 0.046
Malnourished§ 2.11 (0.85–5.35) 0.111 2.19 (0.98–5.01) 0.059
Age <10 y 2.76 (0.40–56.29) 0.377 2.80 (0.60–20.70) 0.235

*Analysis used outcome (death or recovery) and ICU admission as the dependent variables. ICU, intensive care unit; OR, odds ratio.
†0–28 d of age.
Acinetobacter baumannii n = 29; Enterobacteriaceae n = 100 (consisting of Escherichia coli, n = 48; Klebsiella pneumoniae, n = 31; other pathogenic Enterobacteriaceae [consisting of Citrobacter, Enterobacter, Escherichia, Klebsiella, Morganella, Pantoea, Proteus, and Serratia spp. n = 21]).
§Children <10 y of age only.

Main Article

Page created: April 17, 2018
Page updated: April 17, 2018
Page reviewed: April 17, 2018
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