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Volume 24, Number 5—May 2018

Synopsis

Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007–2016

Andrew Fox-LewisComments to Author , Junko Takata, Thyl Miliya, Yoel Lubell, Sona Soeng, Poda Sar, Kolthida Rith, Gregor McKellar, Vanaporn Wuthiekanun, Erin McGonagle, Nicole Stoesser, Catrin E. Moore, Christopher M. Parry, Claudia Turner, Nicholas P.J. Day, Ben S. Cooper, and Paul Turner
Author affiliations: University of Oxford, Oxford, UK (A. Fox-Lewis, J. Takata, Y. Lubell, N. Stoesser, C.E. Moore, C. Turner, N.P.J. Day, B.S. Cooper, P. Turner); Angkor Hospital for Children, Siem Reap, Cambodia (A. Fox-Lewis, T. Miliya, S. Soeng, P. Sar, K. Rith, G. McKellar, C. Turner, P. Turner); Cambodia-Oxford Medical Research Unit, Siem Reap (A. Fox-Lewis, T. Miliya, S. Soeng, P. Sar, K. Rith, C. Turner, P. Turner); Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand (Y. Lubell, V. Wuthiekanun, C.E. Moore, N.P.J. Day, B.S. Cooper); University of Colorado, Aurora, Colorado, USA (E. McGonagle); Liverpool School of Tropical Medicine, Liverpool, UK (C.M. Parry); Nagasaki University, Nagasaki, Japan (C.M. Parry)

Main Article

Table 4

Logistic regression analysis of resistance trends for the gram-negative Global Antimicrobial Resistance Surveillance System pathogen Salmonella enterica serovar Typhi isolated from children at Angkor Hospital for Children, Siem Reap, Cambodia, 2007–2016*

Resistance type, predictor variable
 Univariable analysis
 Multivariable analysis
OR (95% CI)
 p value
 OR (95% CI)
 p value
Fluoroquinolone
Year of isolation
2007–2008 Ref Ref Ref Ref
2009–2010 2.05 (0.47–10.51) 0.345 1.85 (0.42–9.59) 0.422
2011–2012 2.97 (0.82–10.37) 0.085 3.05 (0.83–10.74) 0.080
2013–2014 4.03 × 107 (6.26 × 10−45–∞) 0.992 3.47 × 107 (9.49 × 10−44–∞) 0.992
2015–2016 4.03 × 107 (1.11 × 10−43–∞) 0.992 4.14 × 107 (6.26 × 10−43–∞) 0.991
Patient age, y
>5 Ref Ref Ref Ref
<5
 4.48 (0.87–82.12)
 0.151
4.57 (0.87–84.30)
 0.150
Multidrug
Year of isolation
2007–2008 Ref Ref Ref Ref
2009–2010 1.57 (0.56–4.58) 0.395 1.45 (0.50–4.29) 0.491
2011–2012 4.32 (1.64–11.44) 0.003 4.55 (1.71–12.17) 0.002
2013–2014 2.26 (0.72–7.92) 0.175 2.08 (0.65–7.41) 0.228
2015–2016 0.91 (0.33–2.46) 0.850 0.95 (0.34–2.62) 0.927
Patient age, y
>5 Ref Ref Ref Ref
<5 2.94 (1.22–8.79) 0.029 3.16 (1.28- 9.57) 0.022

*OR, odds ratio; ref, referent.

Main Article

Page created: April 17, 2018
Page updated: April 17, 2018
Page reviewed: April 17, 2018
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