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Volume 24, Number 8—August 2018
Research

Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation

Veronica CostantiniComments to Author , Esther K. Morantz, Hannah Browne, Khalil Ettayebi, Xi-Lei Zeng, Robert L. Atmar, Mary K. Estes, and Jan Vinjé
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (V. Costantini, J. Vinjé); Synergy America, Inc., Atlanta (E.K. Morantz); Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (H. Browne); Baylor College of Medicine, Houston, Texas, USA (K. Ettayebi, X.-L. Zeng, R.L. Atmar, M.K. Estes)

Main Article

Figure 1

Growth of 3-dimensional human intestinal enteroid (HIE) embedded in Matrigel in the presence of complete media with growth factors containing Wnt3a, R-spondin, and Noggin as part of study of human norovirus replication in HIEs. Microscopy images show the growth of a representative undifferentiated HIE: A) day 1; B) day 2; C) day 3; D) day 4; E) day 5; F) day 6; G) day 7; H) day 8; I) day 9; J) day 10. Scale bars indicate 100 μm.

Figure 1. Growth of 3-dimensional human intestinal enteroid (HIE) embedded in Matrigel in the presence of complete media with growth factors containing Wnt3a, R-spondin, and Noggin as part of a study of human norovirus replication in HIEs. Microscopy images show the growth of a representative undifferentiated HIE: A) day 1; B) day 2; C) day 3; D) day 4; E) day 5; F) day 6; G) day 7; H) day 8; I) day 9; J) day 10. Scale bars indicate 100 μm.

Main Article

Page created: July 18, 2018
Page updated: July 18, 2018
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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