Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 1—January 2019
Research

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Joshua E. Sealy, Tahir Yaqub, Thomas P. Peacock1, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, Arslan Mehboob2, Holly Shelton, Juliet E. Bryant, Rod S. Daniels, John W. McCauley, Munir IqbalComments to Author , and Jean-Remy Royal Veterinary CollegeLondonUKSadeyen
Author affiliations: The Pirbright Institute, Pirbright, UK (J.E. Sealy, T.P. Peacock, P. Chang, A. Clements, J.-R. Sadeyen, H. Shelton, M. Iqbal); University of Veterinary and Animal Sciences, Lahore, Pakistan (T. Yaqub, A. Mehboob); The Francis Crick Institute, London (B. Ermetal, R.S. Daniels, J.W. McCauley); Fondation Mérieux, Lyon, France (J.E. Bryant)

Main Article

Figure 1

Genotypes of influenza A(H9N2) viruses from Pakistan. Full genome sequences of 43 contemporary H9N2 avian influenza viruses from Pakistan were used to generate 7 unique genotypes, designated PK1–PK7. Each circle represents a genotype, and n values indicate the total number of viruses assigned to the given genotype. Each line within a circle represents a virus gene segment, and different segment colors between the same gene correspond to a >2% nucleotide difference. Black indicates wild-type v

Figure 1. Genotypes of influenza A(H9N2) viruses from Pakistan. Full-genome sequences of 43 contemporary H9N2 avian influenza viruses from Pakistan were used to generate 7 unique genotypes, designated PK1–PK7. Each circle represents a genotype, and n values indicate the total number of viruses assigned to the given genotype. Each line within a circle represents a virus gene segment, and different segment colors between the same gene correspond to a >2% nucleotide difference. Black indicates wild-type virus genes; red, green, and purple indicate mutated genes. HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic.

Main Article

1Current affiliation: Imperial College London, London, UK.

2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.

Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external