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Volume 25, Number 1—January 2019
Research

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Joshua E. Sealy, Tahir Yaqub, Thomas P. Peacock1, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, Arslan Mehboob2, Holly Shelton, Juliet E. Bryant, Rod S. Daniels, John W. McCauley, Munir IqbalComments to Author , and Jean-Remy Royal Veterinary CollegeLondonUKSadeyen
Author affiliations: The Pirbright Institute, Pirbright, UK (J.E. Sealy, T.P. Peacock, P. Chang, A. Clements, J.-R. Sadeyen, H. Shelton, M. Iqbal); University of Veterinary and Animal Sciences, Lahore, Pakistan (T. Yaqub, A. Mehboob); The Francis Crick Institute, London (B. Ermetal, R.S. Daniels, J.W. McCauley); Fondation Mérieux, Lyon, France (J.E. Bryant)

Main Article

Table 2

Changes in MNT titers influenza A(H9N2) viruses with HA A/T/V180 substitutions*

HA backbone and substitution
 Fold change in MNT titer (titer)†
SKP-827/16
T180A 4‡ (1,024)
T180V
 3§ (4)
UDL-01/08
A180T 3§ (32)
A180V >6§ (2)

*MNT assays were conducted by using antiserum raised against UDL-01/08 as before and RG viruses at 100 50% tissue culture infectious doses. Wild-type virus UDL-01/08 was compared to UDL-01/08 HA backbone variants with A180T and A180V substitutions, and wild-type virus SKP-827/16 was compared with SKP-827/16 HA backbone variants with T180A and T180V substitutions. HA, hemagglutinin; MNT, microneutralization.
†The homologous MNT titer for UDL-01/08 antiserum was 256.
‡Value indicates fold increase,
§Values indicate fold decrease.

Main Article

1Current affiliation: Imperial College London, London, UK.

2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.

Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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