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Volume 25, Number 1—January 2019
Research

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Joshua E. Sealy, Tahir Yaqub, Thomas P. Peacock1, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, Arslan Mehboob2, Holly Shelton, Juliet E. Bryant, Rod S. Daniels, John W. McCauley, Munir IqbalComments to Author , and Jean-Remy Royal Veterinary CollegeLondonUKSadeyen
Author affiliations: The Pirbright Institute, Pirbright, UK (J.E. Sealy, T.P. Peacock, P. Chang, A. Clements, J.-R. Sadeyen, H. Shelton, M. Iqbal); University of Veterinary and Animal Sciences, Lahore, Pakistan (T. Yaqub, A. Mehboob); The Francis Crick Institute, London (B. Ermetal, R.S. Daniels, J.W. McCauley); Fondation Mérieux, Lyon, France (J.E. Bryant)

Main Article

Figure 4

Receptor-binding profiles of influenza A(H9N2) virus isolateses from Pakistan with HA residue 180 substitutions. A, B) UDL-01/08 viruses containing A180T/V substitutions: A) H9N2 A/chicken/Pakistan/UDL-10/2008 A180T; B) H9N2 A/chicken/Pakistan/UDL-10/2008 A180V. C, D) SKP-827/16 viruses containing T180A/V substitutions: C) H9N2 A/chicken/Pakistan/SKP-227/2016 T180A; D) H9N2 A/chicken/Pakistan/SKP-227/2016 T180V. Dashed lines indicate binding profiles of wild-type viruses UDL-01/08 with A180 and

Figure 4. Receptor-binding profiles of influenza A(H9N2) virus isolates from Pakistan with HA residue 180 substitutions. A, B) UDL-01/08 viruses containing A180T/V substitutions: A) H9N2 A/chicken/Pakistan/UDL-10/2008 A180T; B) H9N2 A/chicken/Pakistan/UDL-10/2008 A180V. C, D) SKP-827/16 viruses containing T180A/V substitutions: C) H9N2 A/chicken/Pakistan/SKP-227/2016 T180A; D) H9N2 A/chicken/Pakistan/SKP-227/2016 T180V. Dashed lines indicate binding profiles of wild-type viruses UDL-01/08 with A180 and SKP-827/16 with T180, and solid lines indicate binding profiles of variant viruses. HA, hemagglutinin.

Main Article

1Current affiliation: Imperial College London, London, UK.

2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.

Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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