Volume 25, Number 1—January 2019
Research
Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
Figure 4

Figure 4. Receptor-binding profiles of influenza A(H9N2) virus isolates from Pakistan with HA residue 180 substitutions. A, B) UDL-01/08 viruses containing A180T/V substitutions: A) H9N2 A/chicken/Pakistan/UDL-10/2008 A180T; B) H9N2 A/chicken/Pakistan/UDL-10/2008 A180V. C, D) SKP-827/16 viruses containing T180A/V substitutions: C) H9N2 A/chicken/Pakistan/SKP-227/2016 T180A; D) H9N2 A/chicken/Pakistan/SKP-227/2016 T180V. Dashed lines indicate binding profiles of wild-type viruses UDL-01/08 with A180 and SKP-827/16 with T180, and solid lines indicate binding profiles of variant viruses. HA, hemagglutinin.
1Current affiliation: Imperial College London, London, UK.
2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.
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