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Volume 27, Number 1—January 2021
Research

Comparative Omics Analysis of Historic and Recent Isolates of Bordetella pertussis and Effects of Genome Rearrangements on Evolution

Ana Dienstbier, Fabian Amman, Denisa Petráčková, Daniel Štipl, Jan Čapek, Jana Zavadilová, Kateřina Fabiánová, Jakub Držmíšek, Dilip Kumar, Mark Wildung, Derek Pouchnik, and Branislav VečerekComments to Author 
Author affiliations: Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic (A. Dienstbier, D. Petráčková, D. Štipl, J. Čapek, J. Držmíšek, D. Kumar, B. Večerek); Institute for Theoretical Chemistry of the University of Vienna, Vienna, Austria (F. Amman); National Institute of Public Health, Prague (J. Zavadilová, K. Fabiánová); Washington State University, Pullman, Washington, USA (M. Wildung, D. Pouchnik)

Main Article

Table 2

Genes expressing consistently changed RNA and protein levels in recent and historic isolates of Bordetella pertussis, Czech Republic*

Gene in Tohama I Gene group Gene name Transcriptome Proteome Annotation
toh_00606
 Group_2206
 BP0624
 −2.2
 −2.5
 Substrate-CoA ligase
toh_00607
 Group_2604
 BP0625
 −2.3
 −3.3
 Acyl-CoA dehydrogenase
toh_00609
 Group_2725
 BP0627
 −2.0
 −3.3
 Enoyl-CoA hydratase/isomerase
toh_00610
 Group_895
 BP0628
 −2.4
 −2.8
 Pyruvate dehydrogenase component
toh_00611
 pdhA
 BP0629
 −2.3
 −2.8
 Pyruvate dehydrogenase component
toh_01576
 Group_23
 WP_003811211.1
 −6.8
 −3.3
 Capsular biosynthesis protein
toh_01584
 wza
 BP1628
 −6.8
 −2.2
 Capsular polysaccharide export protein
toh_02732
 Group_1068
 BP2782
 −3.9
 −3.0
 Lipoprotein
toh_02896
 Group_128
 BP2946
 3.6
 2.3
 ArsR family transcriptional regulator
toh_03214
 trpD
 BP3262
 −2.1
 −1.4
 Anthranilate phosphoribosyltransferase
toh_03215
 trpG
 BP3263
 −2.4
 −1.5
 Anthranilate synthase component II
toh_03216
 trpE
 BP3264
 −2.4
 −1.4
 Anthranilate synthase component I
toh_03637
 Group_1064
 BP3695
 3.3
 5.5
 Hydroxymethylglutaryl-CoA lyase
toh_03667 nadC BP3725 2.5 11.8 Nicotinate-nucleotide diphosphorylase

*Fold change values for recent isolates/historic strains comparison are shown for RNA sequencing and proteomic analyses. Values that did not indicate statistical significance (FC>2; adjusted p<0.05) are shown in bold. toh, Tohama

Main Article

Page created: September 01, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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