Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 1—January 2021
Research

Comparative Omics Analysis of Historic and Recent Isolates of Bordetella pertussis and Effects of Genome Rearrangements on Evolution

Ana Dienstbier, Fabian Amman, Denisa Petráčková, Daniel Štipl, Jan Čapek, Jana Zavadilová, Kateřina Fabiánová, Jakub Držmíšek, Dilip Kumar, Mark Wildung, Derek Pouchnik, and Branislav VečerekComments to Author 
Author affiliations: Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic (A. Dienstbier, D. Petráčková, D. Štipl, J. Čapek, J. Držmíšek, D. Kumar, B. Večerek); Institute for Theoretical Chemistry of the University of Vienna, Vienna, Austria (F. Amman); National Institute of Public Health, Prague (J. Zavadilová, K. Fabiánová); Washington State University, Pullman, Washington, USA (M. Wildung, D. Pouchnik)

Main Article

Table 3

Genes expressing consistently increased RNA and protein levels in isolates of Bordetella pertussis and 9 infected patients, Czech Republic, compared with Tohama I*

Gene in Tohama I Gene group Gene name Transcriptome
Proteome
Secretome
Annotation
Cz/Toh VS/Toh Cz/Toh VS/Toh Cz/Toh VS/Toh
toh_00485 Group_1902 BP0500 2.1 2.8 1.5 1.3 6.0 5.1 T3SS effector BopC
toh_00936 Sbp BP0966 14.7 13.0 5.6 4.6 ND ND Sulfate-binding protein
toh_02200 bscI BP2249 2.1 3.1 1.2 ND 2.8 6.2 T3SS protein BscI
toh_02203 bopB BP2252 2.1 3.0 3.1 2.8 2.1 1.8 T3SS protein BopB
toh_02204 bopD BP2253 1.8 2.5 2.0 1.5 3.7 2.3 T3SS protein BopD
toh_02205 bcrH1 BP2254 2.3 4.0 2.5 2.1 1.6 3.1 T3SS protein
toh_02206 Group_1710 BP2255 2.4 3.8 3.9 4.0 4.8 1.7 Hypothetical protein
toh_02207 bsp22 BP2256 2.4 3.6 1.6 1.5 3.6 1.8 T3SS protein Bsp22
toh_02208 bopN BP2257 2.5 2.9 1.3 1.0 3.1 1.5 T3SS protein BopN
toh_02210 Group_2630 BP2259 2.0 2.4 1.4 1.9 5.1 2.4 Putative T3SS protein
toh_02214 bscE BP2263 2.3 1.5 5.2 4.5 2.0 2.3 T3SS protein BscE
toh_03375 Group_1130 BP3434 6.1 4.4 3.3 1.9 2.6 1.8 Exported protein

*Fold change values resulting from comparison of either recent isolates (Cz) or historic strains (VS) with Tohama I strain (Toh) are shown for RNA sequencing and proteomic analyses. Values that did not indicate statistical significance (FC>2; adjusted p<0.05) are shown in bold. ND, not determined; toh, Tohama.

Main Article

Page created: September 01, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external