Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
CDC’s website is being modified to comply with President Trump’s Executive Orders.
Volume 30, Number 8—August 2024
Synopsis

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Lizeth Caraballo, Yaritza Rangel, Armando Reyna-Bello1, Mariana Muñoz, Roque Figueroa-Espinosa2, Carlos E. Sanz-Rodriguez3, Elba Guerrero, Carmen Luisa Loureiro, Qingyun Liu4, and Howard E. TakiffComments to Author 
Author affiliations: Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela (L. Caraballo, Y. Rangel, M. Muñoz, R. Figueroa-Espinosa, C.E. Sanz-Rodriguez, E. Guerrero, C.L. Loureiro, H.E. Takiff); Universidad Nacional Experimental Simón Rodríguez, Caracas (A. Reyna-Bello); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (Q. Liu)

Main Article

Figure 1

Distinguishing clinical features of hospitalized patients in study of outbreak of intermediate species Leptospira venezuelensis spread by rodents to cows and humans in L. interrogans–endemic region, Venezuela. The most statistically different clinical symptoms are shown for hospitalized patients considered to have leptospirosis according to positive PCR for the Leptospria rrs gene in either blood or urine specimens compared with those without leptospirosis according to negative rrs PCR in both blood and urine samples. PCR primers for rrs amplify a region of the gene encoding 16S rRNA that is highly conserved in Leptospira (Appendix Table 1). One patient whose urine culture grew L. venezuelensis was rrs PCR negative, and leptospirosis was not diagnosed (Appendix Table 9). Comparisons of all clinical features with 95% CIs were also determined (Appendix Tables 10, 11). RRs and Pearson χ2 test p values were calculated by using Stata 13 (StataCorp LLC, https://www.stata.com). RR, risk ratio.

Figure 1. Distinguishing clinical features of hospitalized patients in study of outbreak of intermediate species Leptospira venezuelensis spread by rodents to cows and humans in L. interrogans–endemic region, Venezuela. The most statistically different clinical symptoms are shown for hospitalized patients considered to have leptospirosis according to positive PCR for the Leptospria rrs gene in either blood or urine specimens compared with those without leptospirosis according to negative rrs PCR in both blood and urine samples. PCR primers for rrs amplify a region of the gene encoding 16S rRNA that is highly conserved in Leptospira (Appendix Table 1). One patient whose urine culture grew L. venezuelensis was rrs PCR negative, and leptospirosis was not diagnosed (Appendix Table 9). Comparisons of all clinical features with 95% CIs were also determined (Appendix Tables 10, 11). RRs and Pearson χ2 test p values were calculated by using Stata 13 (StataCorp LLC, https://www.stata.com). RR, risk ratio.

Main Article

1Current affiliation: Universidad de las Fuerzas Armadas ESPE, Santo Domingo, Ecuador.

2Current affiliation: Universidad de Buenos Aires, Buenos Aires, Argentina.

3Current affiliation: Institut Pasteur de Montevideo, Montevideo, Uruguay.

4Current affiliation: The University of North Carolina, Chapel Hill, North Carolina, USA.

Page created: May 10, 2024
Page updated: August 07, 2024
Page reviewed: August 07, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external