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Volume 30, Number 8—August 2024
Synopsis

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Lizeth Caraballo, Yaritza Rangel, Armando Reyna-Bello1, Mariana Muñoz, Roque Figueroa-Espinosa2, Carlos E. Sanz-Rodriguez3, Elba Guerrero, Carmen Luisa Loureiro, Qingyun Liu4, and Howard E. TakiffComments to Author 
Author affiliations: Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela (L. Caraballo, Y. Rangel, M. Muñoz, R. Figueroa-Espinosa, C.E. Sanz-Rodriguez, E. Guerrero, C.L. Loureiro, H.E. Takiff); Universidad Nacional Experimental Simón Rodríguez, Caracas (A. Reyna-Bello); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (Q. Liu)

Main Article

Table 1

Tests used for leptospirosis diagnoses in study of outbreak of intermediate species Leptospira venezuelensis spread by rodents to cows and humans in L. interrogans–endemic region, Venezuela*

Diagnostic test† rrs PCR+, n = 37‡ rrs PCR–, n = 34‡ % Sensitivity (95% CI) % Specificity (95% CI) % PPV (95% CI) % NPV (95% CI) % Accuracy (95% CI)
rrs PCR
Blood, + 17 0 46 (30–63) 100 (90–100) 100 (80–100) 63 (56–70) 72 (60–82)
Blood, – 20 34 NA NA NA NA NA
Urine, + 22 0 59 (42–75) 100 (90–100) 100 (85–100) 69 (61–77) 79 (68–88)
Urine, – 15 34 NA NA NA NA NA
Both, +
 2
 0
 NA
 NA
 NA
 NA
 NA
Culture
Blood, + 16 0 43 (27–61) 100 (90–100) 100 (80–100) 62 (55–68) 70 (58–81)
Urine, + 22 1 59 (42–75) 97 (85–100) 96 (76–99) 69 (60–77) 77 (66–87)
Either, +
 35
 1
 95 (82–99)
 97 (85–100)
 97 (84–100)
 94 (81–98)
 96 (88–99)
lipL32 PCR
Blood, + 15 0 41 (25–58) 100 (90–100) 100 (78–100) 61 (54–67) 69 (57–79)
Urine, + 13 0 35 (20–53) 100 (90–100) 100 (75–100) 59 (53–64) 66 (54–77)
Either, + 26 0 70 (53–84) 100 (90–100) 100 (87–100) 76 (65–84) 85 (74–92)

*Diagnostic values were obtained for Leptospira cultures and PCR of Leptospira lipL32 and Leptospira rrs (16S rDNA) genes of blood and urine specimens from hospitalized patients. NA, not applicable; NPV, negative predictive value; PPV, positive predictive value; –, negative; +, positive. †Test results are shown for patients who had Leptospira detected in blood, urine, or either blood or urine. ‡Total numbers of study patients who had the Leptospira rrs gene detected by PCR of either blood or urine samples.

Main Article

1Current affiliation: Universidad de las Fuerzas Armadas ESPE, Santo Domingo, Ecuador.

2Current affiliation: Universidad de Buenos Aires, Buenos Aires, Argentina.

3Current affiliation: Institut Pasteur de Montevideo, Montevideo, Uruguay.

4Current affiliation: The University of North Carolina, Chapel Hill, North Carolina, USA.

Page created: May 10, 2024
Page updated: August 07, 2024
Page reviewed: August 07, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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