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Volume 30, Number 8—August 2024
Research

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Zoe J. Lambert1, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, and Justin J. GreenleeComments to Author 
Author affiliations: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (Z.J. Lambert); US Department of Agriculture, Ames, Iowa, USA (Z.J. Lambert, J. Bian, E.D. Cassmann, J.J. Greenlee); Iowa State University, Ames (Z.J. Lambert, M.H. West Greenlee)

Main Article

Figure 2

Epitope mapping on Western blots with antibodies that progress toward the N-terminal of the prion protein in study of scrapie versus CWD in white-tailed deer. C-terminal antibodies 6H4 (A) and SHA31 (B) were used to probe brain and lymphoid tissue (representative samples). C) Material from the second passage of WTD scrapie and CWD, both responsive to probing by the N-terminal antibody 12B2. D) WTD scrapie material showing no or low affinity to the N-terminal antibody P4. Cbrum, cerebrum; CWD, chronic wasting disease; P1, first passage; rpln, retropharyngeal lymph node; sc, cervical spinal cord; WTD, white-tailed deer.

Figure 2. Epitope mapping on Western blots with antibodies that progress toward the N-terminal of the prion protein in study of scrapie versus CWD in white-tailed deer. C-terminal antibodies 6H4 (A) and SHA31 (B) were used to probe brain and lymphoid tissue (representative samples). C) Material from the second passage of WTD scrapie and CWD, both responsive to probing by the N-terminal antibody 12B2. D) WTD scrapie material showing no or low affinity to the N-terminal antibody P4. Cbrum, cerebrum; CWD, chronic wasting disease; P1, first passage; rpln, retropharyngeal lymph node; sc, cervical spinal cord; WTD, white-tailed deer.

Main Article

1Current affiliation: Des Moines University, Des Moines, Iowa, USA.

Page created: June 14, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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