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Volume 30, Number 8—August 2024
Research

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Zoe J. Lambert1, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, and Justin J. GreenleeComments to Author 
Author affiliations: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (Z.J. Lambert); US Department of Agriculture, Ames, Iowa, USA (Z.J. Lambert, J. Bian, E.D. Cassmann, J.J. Greenlee); Iowa State University, Ames (Z.J. Lambert, M.H. West Greenlee)

Main Article

Table 1

Two-fold dilutions of brainstem inoculum in cervidized mice inoculated with WTD deer scrapie agent, passage 1 or 2, compared with WTD CWD agent*

Weight/ volume, % WTD CWD WTD scrapie agent
Passage 1 Passage 2
10 3.847 3.758 4
5 3.721 3.395 4
1 3.657 1.973 3.784
0.50 3.828 1.363 3.291
0.25 3.643 0.674 2.74
0.125 3.224 0.432 1.808
0.0625 2.354 0.244 1
0.031 1.345 0.138 0.439

*The optical density of brainstem samples after 2-fold dilutions to compare relative load of misfolded prion protein in the inoculum (1% wt/vol) of cervidized mice (Tg12). CWD, chronic wasting disease; WTD, white-tailed deer.

Main Article

1Current affiliation: Des Moines University, Des Moines, Iowa, USA.

Page created: June 14, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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