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Volume 30, Number 8—August 2024
Research

Scrapie Versus Chronic Wasting Disease in White-Tailed Deer

Zoe J. Lambert1, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, and Justin J. GreenleeComments to Author 
Author affiliations: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (Z.J. Lambert); US Department of Agriculture, Ames, Iowa, USA (Z.J. Lambert, J. Bian, E.D. Cassmann, J.J. Greenlee); Iowa State University, Ames (Z.J. Lambert, M.H. West Greenlee)

Main Article

Table 2

Misfolded prion protein presence and accumulation in multiple tissues from 3 white-tailed deer with white-tailed deer scrapie

Identification
Deer 1
 Deer 2
 Deer 3
Animal data
Genotype (95/96)† QQ/GG QQ/GG QQ/GG
Incubation period, mo after inoculation 25.6 21 25.8
EIA OD
Brainstem 4 3.26 1.79
Cerebrum 4 Not detected Not detected
Retina 4 Not detected Not detected
Retropharyngeal lymph nodes
 4
 4
 4
Spongiform lesion on brainstem
 +
 +
 +
Immunohistochemistry
Antemortem rectal biopsy (17 mpi) + Insufficient +
Brainstem + + +
Cerebrum + Not detected Not detected
Retina + + +
Retropharyngeal lymph nodes + + +
Palatine tonsil + + +

*EIA OD, enzyme immunoassay optical density. †Homozygous for glutamine at codon 95 and glycine at codon 96 (QQ95/GG96) of the PRNP gene.

Main Article

1Current affiliation: Des Moines University, Des Moines, Iowa, USA.

Page created: June 14, 2024
Page updated: July 16, 2024
Page reviewed: July 16, 2024
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