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Volume 30, Number 8—August 2024
Research

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Zoe J. Lambert1, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, and Justin J. GreenleeComments to Author 
Author affiliations: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (Z.J. Lambert); US Department of Agriculture, Ames, Iowa, USA (Z.J. Lambert, J. Bian, E.D. Cassmann, J.J. Greenlee); Iowa State University, Ames (Z.J. Lambert, M.H. West Greenlee)

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Figure 4

Denaturation curves comparing the conformational stability of scrapie (misfolded) form of prion protein (PrPSc) in the cervical spinal cords of white-tailed deer with passage 2 WTD scrapie agent, passage 1 WTD scrapie agent, and CWD agent in study of scrapie versus CWD in white-tailed deer. The PrPSc conformational stability of like tissues did not differ significantly. CWD, chronic wasting disease; Fapp, apparent fractional change of unfolded PrPSc; GdnHCl, guanidine hydrochloride; M, molar; WTDsc-p1, passage 1 WTD scrapie; WTDsc-p2, passage 2 WTD scrapie.

Figure 4. Denaturation curves comparing the conformational stability of scrapie (misfolded) form of prion protein (PrPSc) in the cervical spinal cords of white-tailed deer with passage 2 WTD scrapie agent, passage 1 WTD scrapie agent, and CWD agent in study of scrapie versus CWD in white-tailed deer. The PrPSc conformational stability of like tissues did not differ significantly. CWD, chronic wasting disease; Fapp, apparent fractional change of unfolded PrPSc; GdnHCl, guanidine hydrochloride; M, molar; WTDsc-p1, passage 1 WTD scrapie; WTDsc-p2, passage 2 WTD scrapie.

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1Current affiliation: Des Moines University, Des Moines, Iowa, USA.

Page created: June 14, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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