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Volume 31, Number 12—December 2025

Research

Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice

Natalia Fernández-Borges1, Alba Marín-Moreno1, Juan Carlos Espinosa, Sara Canoyra, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA-CSIC), Madrid, Spain (N. Fernández-Borges, A. Marín-Moreno, J.C. Espinosa, S. Canoyra, J.M. Torres); Interactions Hôte Agent Pathogène–École Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Figure 5

Paraffin-embedded tissue blotting results of brain tissues in study of propagation of classical scrapie prions. Images are of brain specimens from 3 distinct K222-Tg516 mice inoculated with CP060146/K222 goat isolate. Results are visualized with the Sha31 monoclonal antibody. A) Cerebellum specimens. B) Thalamus specimens. C) Hippocampus specimens. D) Cerebral cortex specimens. Proteinase K–resistant prion protein is visible as dark staining in similar brain regions in the 3 mice. Original magnification ×20.

Figure 5. Paraffin-embedded tissue blotting results of brain tissues in study of propagation of classical scrapie prions. Images are of brain specimens from 3 distinct K222-Tg516 mice inoculated with CP060146/K222 goat isolate. Results are visualized with the Sha31 monoclonal antibody. A) Cerebellum specimens. B) Thalamus specimens. C) Hippocampus specimens. D) Cerebral cortex specimens. Proteinase K–resistant prion protein is visible as dark staining in similar brain regions in the 3 mice. Original magnification ×20.

Main Article

1These first authors contributed equally to this article.

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Page updated: January 01, 2026
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