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Volume 31, Number 12—December 2025

Research

Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice

Natalia Fernández-Borges1, Alba Marín-Moreno1, Juan Carlos Espinosa, Sara Canoyra, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA-CSIC), Madrid, Spain (N. Fernández-Borges, A. Marín-Moreno, J.C. Espinosa, S. Canoyra, J.M. Torres); Interactions Hôte Agent Pathogène–École Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Figure 4

Immunohistochemistry results of brain tissues in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with CP060146/K222 goat isolate. Results are visualized using the Sha31 monoclonal antibody. A) Hippocampus specimen tested at first passage. B) Midbrain specimen tested at first passage. C) Hippocampus specimen tested at second passage. D) Midbrain specimen tested at second passage. Original magnification ×40.

Figure 4. Immunohistochemistry results of brain tissues in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with CP060146/K222 goat isolate. Results are visualized using the Sha31 monoclonal antibody. A) Hippocampus specimen tested at first passage. B) Midbrain specimen tested at first passage. C) Hippocampus specimen tested at second passage. D) Midbrain specimen tested at second passage. Original magnification ×40.

Main Article

1These first authors contributed equally to this article.

Page created: November 17, 2025
Page updated: January 01, 2026
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