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Volume 31, Number 12—December 2025

Research

Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice

Natalia Fernández-Borges1, Alba Marín-Moreno1, Juan Carlos Espinosa, Sara Canoyra, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA-CSIC), Madrid, Spain (N. Fernández-Borges, A. Marín-Moreno, J.C. Espinosa, S. Canoyra, J.M. Torres); Interactions Hôte Agent Pathogène–École Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Figure 3

Immunohistochemistry results of brain tissue in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with F10 goat scrapie isolate at second passage. Results are visualized using the Sha31 monoclonal antibody. A) Thalamus specimen. B) Hippocampus specimen. C) Midbrain specimen.

Figure 3. Immunohistochemistry results of brain tissue in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with F10 goat scrapie isolate at second passage. Results are visualized using the Sha31 monoclonal antibody. A) Thalamus specimen. B) Hippocampus specimen. C) Midbrain specimen.

Main Article

1These first authors contributed equally to this article.

Page created: November 17, 2025
Page updated: December 23, 2025
Page reviewed: December 23, 2025
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