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Volume 31, Number 12—December 2025

Research

Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice

Natalia Fernández-Borges1, Alba Marín-Moreno1, Juan Carlos Espinosa, Sara Canoyra, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA-CSIC), Madrid, Spain (N. Fernández-Borges, A. Marín-Moreno, J.C. Espinosa, S. Canoyra, J.M. Torres); Interactions Hôte Agent Pathogène–École Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Figure 3

Immunohistochemistry results of brain tissue in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with F10 goat scrapie isolate at second passage. Results are visualized using the Sha31 monoclonal antibody. A) Thalamus specimen. B) Hippocampus specimen. C) Midbrain specimen. Original magnification ×40.

Figure 3. Immunohistochemistry results of brain tissue in study of propagation of classical scrapie prions. Images are of tissue specimens from K222-Tg516 mice inoculated with F10 goat scrapie isolate at second passage. Results are visualized using the Sha31 monoclonal antibody. A) Thalamus specimen. B) Hippocampus specimen. C) Midbrain specimen. Original magnification ×40.

Main Article

1These first authors contributed equally to this article.

Page created: November 17, 2025
Page updated: January 01, 2026
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