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Volume 32, Number 1—January 2026

Research

Enhanced Isolation and Detection of COVID-19 in Hospitalized Patients Undergoing Antiviral Therapy

Ranawaka A.P.M. PereraComments to Author , Andrew Marques, Jevon Graham-Wooten, Li Hui Tan, Noam Cohen, Kyle Rodino, Ronald G. Collman, Frederic D. Bushman, and Susan R. Weiss
Author affiliation: Department of Veterans Affairs, Philadelphia, Pennsylvania, USA (R.A.P.M. Perera); University of Pennsylvania, Philadelphia (R.A.P.M. Perera, A. Marques, J. Graham-Wooten, L.H. Tan, N. Cohen, K. Rodino, R.G. Collman, F.D. Bushman, S.R. Weiss)

Main Article

Figure 2

Viral culture isolation rates from nasal swabs of nonimmunocompromised patients infected with SARS-CoV-2 variants of concern from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. Nasal swabs (n = 148) PCR-confirmed positive for wild-type, Delta, BA.1, BA.2, BQ, BA.5, and XBB.1 SARS-CoV-2 variants of concern were cultured in triplicate on 3 different cell lines. Error bars indicate SDs. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Figure 2. Viral culture isolation rates from nasal swabs of nonimmunocompromised patients infected with SARS-CoV-2 variants of concern from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. Nasal swabs (n = 148) PCR-confirmed positive for wild-type, Delta, BA.1, BA.2, BQ, BA.5, and XBB.1 SARS-CoV-2 variants of concern were cultured in triplicate on 3 different cell lines. Error bars indicate SDs. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Main Article

Page created: December 30, 2025
Page updated: January 29, 2026
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